ArticleProceedings of the National Academy of Sciences of the United States of America2006
Long-range multilocus haplotype phasing of the MHC.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Haplotypes analysis reveals the genetic basis of type I CD36 deficiency.Scientific reports · 2024Article
- Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.International journal of immunogenetics · 2021Article
- SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction.Frontiers in genetics · 2020Article
- Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation.F1000Research · 2017Review
- Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq.BMC genomics · 2015Article
- Dominant sequences of human major histocompatibility complex conserved extended haplotypes from HLA-DQA2 to DAXX.PLoS genetics · 2014Article
- Genomic biomarkers correlate with HLA-identical renal transplant tolerance.Journal of the American Society of Nephrology : JASN · 2013Article
- Genetics of graft-versus-host disease: the major histocompatibility complex.Blood reviews · 2013Review
- A comprehensively molecular haplotype-resolved genome of a European individual.Genome research · 2011Article
- Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation.DNA research : an international journal for rapid publication of reports on genes and genomes · 2011Article
- A hidden two-locus disease association pattern in genome-wide association studies.BMC bioinformatics · 2011Article
- Strobe sequence design for haplotype assembly.BMC bioinformatics · 2011Article
- Whole-genome molecular haplotyping of single cells.Nature biotechnology · 2011Article
- Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.Annals of the New York Academy of Sciences · 2010Review
- New advances in hematopoietic cell transplantation.Current opinion in hematology · 2008Review
- Hematopoietic transplantation from adult unrelated donors as treatment for acute myeloid leukemia.Bone marrow transplantation · 2008Review
- Mapping MHC-resident transplantation determinants.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2007Article
- MHC haplotype matching for unrelated hematopoietic cell transplantation.PLoS medicine · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Haplotypes are a powerful tool for identifying the genetic basis of common complex diseases. Disease-association mapping requires molecular methods for haplotyping biallelic SNP variation and highly complex polymorphisms. We developed a method for phasing HLA-A, HLA-B, and HLA-DRB1 alleles on chromosome 6 in unrelated individuals. This method uses the highly polymorphic HLA-B locus to discriminate the two HLA haplotypes in heterozygous individuals and its ideal location 1.4 Mbp telomeric to HLA-DRB1 and 1.2 Mbp centromeric to HLA-A to capture 2-Mbp-long genomic DNA. Genomic DNA representing a single HLA-B-captured haplotype is genotyped for HLA-A and HLA-DRB1 alleles and linkage to HLA-B is established. Proof of principle was established in a large blinded study of phase-known samples. Availability of an efficient method for MHC haplotype phase determination will facilitate the mapping of causative MHC-resident genes in many human diseases and has the potential to be broadened to other polymorphic gene complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.