ArticleFree radical biology & medicine2006
gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.
Article in Free radical biology & medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.Annals of clinical and translational neurology · 2019Trial
- Managing Aminotransferase Elevations in Patients with Friedreich Ataxia Treated with Omaveloxolone: A Review and Expert Opinion on Use Considerations.Neurology and therapy · 2025Review
- Appraising the Role of Astrocytes as Suppliers of Neuronal Glutathione Precursors.International journal of molecular sciences · 2023Review
- RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model.BMC genomics · 2021Article
- Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.Neurochemical research · 2019Article
- 4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways.Oxidative medicine and cellular longevity · 2019Review
- Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity.Free radical biology & medicine · 2017Review
- 4-hydroxynonenal-mediated signaling and aging.Free radical biology & medicine · 2017Review
- Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles.Free radical biology & medicine · 2017Article
- Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis.Journal of neurochemistry · 2016Article
- Oxidative stress response and Nrf2 signaling in aging.Free radical biology & medicine · 2015Review
- N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Independent and co-morbid HIV infection and Meth use disorders on oxidative stress markers in the cerebrospinal fluid and depressive symptoms.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism.Archives of biochemistry and biophysics · 2015Article
- Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.Molecular and cellular biology · 2014Article
- Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic.Antioxidants & redox signaling · 2014Article
- Reexamination of the electrophile response element sequences and context reveals a lack of consensus in gene function.Biochimica et biophysica acta · 2010Article
- Redox regulation of gamma-glutamyl transpeptidase.American journal of respiratory cell and molecular biology · 2009Review
- Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element.Free radical biology & medicine · 2009Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
gamma-Glutamyl transpeptidase (GGT) plays key roles in glutathione homeostasis and metabolism of glutathione S-conjugates. Rat GGT is transcribed via five tandemly arranged promoters into seven transcripts. The transcription of mRNA V is controlled by promoter 5. Previously we found that GGT mRNA V-2 was responsible for the induction of GGT in rat alveolar epithelial cells by 4-hydroxynonenal (HNE). In the current study, the underlying mechanism was investigated. Reporter deletion and mutation analysis demonstrated that an electrophile-response element (EpRE) in the proximal region of GGT promoter 5 (GP5) was responsible for the basal- and HNE-induced promoter activity. Gel-shift assays showed an increased binding activity of GP5 EpRE after HNE exposure. The nuclear content of NF-E2-related factor 2 (Nrf2) was significantly increased by HNE. The recruitment of Nrf2 to GP5 EpRE after HNE treatment was demonstrated by supershift and chromatin immunoprecipitation assays. The tissue expression pattern of GGT mRNA V was previously unknown. Using polymerase chain reaction, we found that GGT mRNA V-2 was expressed in many tissues in rat. Taken together, GGT mRNA V-2 is widely expressed in rat tissues and its basal and HNE-induced expression is mediated through EpRE/Nrf2 signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.