SynthesisBiological psychiatry2006
Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples.
Synthesis in Biological psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 99 citations in OpenAlex.
- Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia.Biological psychiatry · 2008Trial
- Immune synaptopathies: how maternal immune activation impacts synaptic function during development.The EMBO journal · 2023Review
- The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders.Advances in neurobiology · 2023Article
- Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.Immunity · 2021Article
- Association Analysis Between SNPs in the Promoter Region ofNeuropsychiatric disease and treatment · 2020Article
- Association between RGS4 variants and psychotic-like experiences in nonclinical individuals.European archives of psychiatry and clinical neuroscience · 2017Article
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.Psychopharmacology · 2013Article
- RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells.Journal of neurochemistry · 2012Article
- Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.Behavioral and brain functions : BBF · 2012Article
- Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.Frontiers in genetics · 2012Article
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Contribution of nonprimate animal models in understanding the etiology of schizophrenia.Journal of psychiatry & neuroscience : JPN · 2011Review
- Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders.Behavioral neuroscience · 2011Review
- Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature.BMC genetics · 2011Article
- Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains.Biological psychiatry · 2011Review
- Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia.The American journal of psychiatry · 2010Article
- RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample.Schizophrenia bulletin · 2010Article
- Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.Schizophrenia bulletin · 2010Article
- Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
Corrections and comments
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Authors and funding
36 authors at 17 institutions in 7 countries.
Funding
Abstract
backgroundAssociations between schizophrenia (SCZ) and polymorphisms at the regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18). Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles.
methodsIn an effort to resolve the role for RGS4 in SCZ susceptibility, we undertook a genotype-based meta-analysis using both published and unpublished family-based and case-control samples (total n = 13,807).
resultsThe family-based dataset consisted of 10 samples (2160 families). Significant associations with individual SNPs/haplotypes were not observed. In contrast, global analysis revealed significant transmission distortion (p = .0009). Specifically, analyses suggested overtransmission of two common haplotypes that account for the vast majority of all haplotypes. Separate analyses of 3486 cases and 3755 control samples (eight samples) detected a significant association with SNP 4 (p = .01). Individual haplotype analyses were not significant, but evaluation of test statistics from individual samples suggested significant associations.
conclusionsOur collaborative meta-analysis represents one of the largest SCZ association studies to date. No individual risk factor arose from our analyses, but interpretation of these results is not straightforward. Our analyses suggest risk due to at least two common haplotypes in the presence of heterogeneity. Similar analysis for other putative susceptibility genes is warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.