ArticleThe Journal of allergy and clinical immunology2006
Decreased CD4+ lymphocytes and innate immune responses in adults with previous extrapulmonary tuberculosis.
Article in The Journal of allergy and clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Identifying the Interaction Between Tuberculosis and SARS-CoV-2 Infections via Bioinformatics Analysis and Machine Learning.Biochemical genetics · 2024Article
- Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active Tuberculosis.International journal of molecular sciences · 2023Review
- Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis.Frontiers in immunology · 2020Article
- Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis.BMC infectious diseases · 2019Article
- Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study.Scientific reports · 2019Observational
- Diabetes mellitus and extrapulmonary tuberculosis: site distribution and risk of mortality.Epidemiology and infection · 2016Article
- Tuberculosis and the risk of infection with other intracellular bacteria: a population-based study.Epidemiology and infection · 2015Article
- 25-Hydroxyvitamin D levels after recovery from tuberculosis: insights into pathogenesis.Tuberculosis (Edinburgh, Scotland) · 2014Article
- Abnormal immune responses in persons with previous extrapulmonary tuberculosis in an in vitro model that simulates in vivo infection with Mycobacterium tuberculosis.Clinical and vaccine immunology : CVI · 2012Article
- Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases.Revista da Sociedade Brasileira de Medicina Tropical · 2012Article
- Increased frequency of regulatory T cells and T lymphocyte activation in persons with previously treated extrapulmonary tuberculosis.Clinical and vaccine immunology : CVI · 2012Article
- Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study.BMC research notes · 2011Article
- Diagnosis of gastrointestinal tuberculosis: Using cytomorphological, microbiological, immunological and molecular techniques - A study from Central India.Indian journal of clinical biochemistry : IJCB · 2010Article
- Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.BMC medical genetics · 2010Article
- Black race, sex, and extrapulmonary tuberculosis risk: an observational study.BMC infectious diseases · 2010Article
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8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundCD4+ lymphocytes control Mycobacterium tuberculosis infection through cytokine-mediated macrophage activation. Extrapulmonary tuberculosis is presumably a marker of immunodeficiency, but cytokine responses have not been well studied in such patients.
objectiveAssess immune defects in persons with previous extrapulmonary tuberculosis.
methodsIn vitro cytokine responses of PBMCs from HIV-seronegative adults with previous extrapulmonary tuberculosis (n = 10) were compared with responses from persons with previous pulmonary tuberculosis (n = 24) and latent M tuberculosis infection (n = 30) in a case-control study.
resultsPatients and controls did not differ according to age, sex, race, or monocytes. The median time between tuberculosis diagnosis and study entry was 72 and 122 weeks in extrapulmonary and pulmonary patients, respectively (P = .2). Median CD4+ counts were 660, 814, and 974 lymphocytes/mm3 in extrapulmonary, pulmonary, and latently infected patients, respectively (P = .03). At 48 hours, median unstimulated cytokine levels were uniformly lower in extrapulmonary patients than both sets of controls. These differences persisted after controlling for CD4+ count by linear regression analysis. Despite lower unstimulated levels, median TNF-alpha response was higher in patients with extrapulmonary and pulmonary tuberculosis than latently infected persons after stimulation with PHA 1% (P = .006) and PHA+IL-12 (1 ng/mL; P = .02); IL-10 remained low in patients with extrapulmonary tuberculosis after the same stimuli (P = .04 and .06, respectively). There was no primary immunodeficiency in the IL-12/23-IFN-gamma axis.
conclusionHIV-seronegative adults with previous extrapulmonary tuberculosis had lower CD4+ lymphocytes and unstimulated cytokine production. This suggests a subtle abnormality in innate immune function. CLINICAL IMPLICATIONS: These characteristics could identify persons at risk for severe tuberculosis manifestations.
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