ArticleThe Journal of allergy and clinical immunology2006
Etanercept treatment of cutaneous granulomas in common variable immunodeficiency.
Article in The Journal of allergy and clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- What Works When Treating Granulomatous Disease in Genetically Undefined CVID? A Systematic Review.Frontiers in immunology · 2020Pooled it
- Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID).Journal of clinical immunology · 2013Trial
- Clinical and experimental treatment of primary humoral immunodeficiencies.Clinical and experimental immunology · 2024Review
- Biologic Therapies for the Management of Cutaneous Findings in Genodermatoses: A Review.American journal of clinical dermatology · 2022Review
- Precision medicine: The use of tailored therapy in primary immunodeficiencies.Frontiers in immunology · 2022Review
- A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.Clinical immunology (Orlando, Fla.) · 2019Article
- Common variable immune deficiency: Dissection of the variable.Immunological reviews · 2019Review
- Treatment of Granulomas in Patients With Ataxia Telangiectasia.Frontiers in immunology · 2018Article
- The development and assessment of biological treatments for children.British journal of clinical pharmacology · 2015Review
- Infliximab for treatment of granulomatous disease in patients with common variable immunodeficiency.Journal of clinical immunology · 2014Article
- Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency.The Journal of allergy and clinical immunology · 2014Article
- Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients.Journal of clinical immunology · 2013Review
- How I treat common variable immune deficiency.Blood · 2010Review
- Cutaneous granulomatosis and combined immunodeficiency revealing Ataxia-Telangiectasia: a case report.Italian journal of pediatrics · 2010Article
- Granulomatous disease in common variable immunodeficiency.Clinical immunology (Orlando, Fla.) · 2009Article
- Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions.British journal of haematology · 2009Review
- Clinical immunology review series: An approach to the management of pulmonary disease in primary antibody deficiency.Clinical and experimental immunology · 2009Review
- Common variable immunodeficiency associated with inflammatory bowel disease and type I diabetes.Clinical medicine. Case reports · 2009Article
- Common variable immunodeficiency-associated myelitis: report of treatment with infliximab.Journal of neurology · 2008Article
- A middle-aged female with recurrent sinopulmonary infections: a case report.Journal of medical case reports · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia, poor antibody responses, and recurrent bacterial infections, usually of the sinorespiratory tract. A not uncommon complication is granuloma of the lungs, spleen, liver, and/or skin. We report the case of an 18-year-old boy with CVID and chronic granulomas of the left arm (since 13 years of age) refractory to treatment with antibiotics, intravenous immunoglobulin, antifungal agents, systemic and intralesional steroids, IFN-gamma, cyclosporine, methotrexate, hydroxychloroquine, localized radiation therapy, and surgical excision. The lesions improved after treatment with the systemic administration of the TNF-alpha inhibitor etanercept for 1 year. Etanercept prevents soluble TNF from binding to its cell membrane receptor, leading to inhibition of its inflammatory cascade. We recommend further trials of etanercept in patients with CVID with noninfectious recalcitrant granulomas.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.