TACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiency.

Lucinda J Berglund, Graham J Jones, Rajmohan Murali, David A Fulcher

Open access · bronzeAbstract readCase Reports

In one paragraph

Article in The Journal of allergy and clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.7field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

Re-evaluation of the contribution ofJournal of human immunity · 2025
Article
Renal Manifestations of Common Variable Immunodeficiency.Kidney360 · 2020
Article

4 · The record

Corrections and comments

Commented on by
The last 80 years in primary immunodeficiency: how far have we come, how far need we go?2006

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lucinda J BerglundImmunology Unit, Westmead Hospital, Westmead, Sydney, NSW, Australia.

Graham J Jones

Rajmohan Murali

David A Fulcher

Westmead Hospital · AUWestmead Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations of the gene encoding the TNF receptor family member transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), TNFSRF13B, have recently been described in patients with common variable immunodeficiency (CVID). We report the case of a man with CVID in association with a heterozygous TACI gene mutation (C104R) who had a highly unusual, invasive, polyclonal CD8+ T-cell lymphoproliferation resulting in massive hepatosplenomegaly and causing renal impairment because of infiltration. Although lymphoproliferation is well described in CVID, the key features in this patient included the T-cell origin of the lymphoproliferation, its polyclonal nature, its infiltration into multiple organs, and the presence of the TACI gene mutation.

Indexed as

Point MutationAdultBase SequenceCD8-Positive T-LymphocytesCommon Variable ImmunodeficiencyDiagnosis, DifferentialDNADNA Mutational AnalysisHumansLymphoproliferative DisordersMaleMembrane ProteinsModels, ImmunologicalReceptors, Tumor Necrosis FactorTransmembrane Activator and CAML Interactor ProteinDNAMembrane ProteinsReceptors, Tumor Necrosis FactorTNFRSF13B protein, humanTransmembrane Activator and CAML Interactor Protein

Identifiers

PMID16630947

DOI10.1016/j.jaci.2006.01.004

OpenAlexW2108793518

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.