Evidence map›Paper›PMID 16630930›Full record

ArticleThe Journal of allergy and clinical immunology2006

Primary immunodeficiency or not? Making the correct diagnosis.

Rebecca H Buckley

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Inborn Errors of Immunity: New Insights.Acta medica academica · 2024
    Review
  2. Article
  3. Article
  4. Patterns of Allergic Sensitization in High IgE Syndromes.Current allergy and asthma reports · 2015
    Review
  5. Review
  6. Article
  7. Review
  8. Newborn screening for severe combined immunodeficiency: an opportunity for intervention.Journal of perinatology : official journal of the California Perinatal Association · 2013
    Article
  9. Article
  10. Review
  11. Article
  12. Common variable immunodeficiency: etiological and treatment issues.International archives of allergy and immunology · 2009
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Rebecca H BuckleyDuke University School of Medicine, Durham, NC 27710, USA. buckL003@mc.duke.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Making a correct diagnosis of a primary immunodeficiency disease is crucial for the selection of proper therapy. Although many cases go undiagnosed, there are also many instances of incorrect diagnosis that result in years of inappropriate treatment and failure to implement beneficial treatment. This article summarizes 2 actual cases in which incorrect diagnoses led to recommendations of unwarranted high-risk or costly treatments. Had the physicians chosen tests of immune function rather than relying on immunoglobulin levels or cell counts, they would have arrived at the true diagnoses.

Indexed as

AdolescentCommon Variable ImmunodeficiencyDiagnostic ErrorsHumansImmunoglobulins, IntravenousImmunologic Deficiency SyndromesInfantLymphangiectasis, IntestinalMaleRespiratory HypersensitivitySevere Combined ImmunodeficiencySkin TestsImmunoglobulins, Intravenous

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.