ReviewThe Journal of allergy and clinical immunology2006
Molecular basis of common variable immunodeficiency.
Review in The Journal of allergy and clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 90 citations in OpenAlex.
- Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.The Journal of allergy and clinical immunology · 2019Trial
- Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Immune abnormalities in IgA nephropathy.Clinical kidney journal · 2023Review
- Insights from a Case of Good's Syndrome (Immunodeficiency with Thymoma).Biomedicines · 2023Article
- New approach to investigate Common Variable Immunodeficiency patients using spectrochemical analysis of blood.Scientific reports · 2019Article
- End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.Clinical nephrology. Case studies · 2019Article
- Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID).Journal of clinical immunology · 2018Article
- Modulation of the Interleukin-21 Pathway with Interleukin-4 Distinguishes Common Variable Immunodeficiency Patients with More Non-infectious Clinical Complications.Journal of clinical immunology · 2018Article
- Use of subcutaneous immunoglobulin in primary immune deficiencies.Turk pediatri arsivi · 2016Article
- Development, manufacturing and characterization of a highly purified, liquid immunoglobulin g preparation from human plasma.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Article
- Primary vs. secondary antibody deficiency: clinical features and infection outcomes of immunoglobulin replacement.PloS one · 2014Article
- Common variable immune deficiency in children--clinical characteristics varies depending on defect in peripheral B cell maturation.Journal of clinical immunology · 2013Article
- Clinical variability of family members with the C104R mutation in transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI).Journal of clinical immunology · 2013Article
- Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.Annual review of medicine · 2013Review
- The spectrum of disease manifestations in patients with common variable immunodeficiency disorders and partial antibody deficiency in a university hospital.Journal of clinical immunology · 2012Article
- Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits.Genome biology · 2011Article
- Clinical consequences of defects in B-cell development.The Journal of allergy and clinical immunology · 2010Review
- Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8.BMC medical genetics · 2009Article
- Genetic polymorphism study of regulatory B cell molecules and cellular immunity function in an adult patient with Common Variable Immunodeficiency.Hippokratia · 2008Article
- Immunodeficiency, radiosensitivity, and the XCIND syndrome.Immunologic research · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is the most prevalent human primary immunodeficiency requiring medical attention. Until recently, the only known genetic defect specific to CVID was the inducible costimulatory receptor (ICOS) deficiency, which accounts for less than 1% of the patients. Recently, mutations in the TNF receptor family member transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), which mediates isotype switching in B cells, were found to be present in 10% to 20% of patients with CVID. Mutations in TACI were also found in relatives of patients with CVID who had IgA deficiency (IgAD), as well as in a patient with isolated IgAD. In the majority of patients described to date, only one TACI allele is mutated, showing an autosomal dominant transmission of the disease. B cells from individuals with TACI mutations did not produce IgG and IgA in response to the TACI ligand a proliferation-inducing ligand (APRIL), probably reflecting impaired isotype switching. These results suggest that TACI mutations can lead to CVID and IgAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.