ArticleImmunology1991
Tumour necrosis factor receptor distribution in human lymphoid tissue.
Article in Immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A.Antioxidants & redox signaling · 2010Review
- Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.Rheumatology international · 2009Article
- Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene.Genes and immunity · 2003Article
- Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.Journal of virology · 1999Article
- Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration.Immunology · 1997Article
- Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells.Immunology · 1996Article
- Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture.Immunology · 1996Article
- Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.Immunology · 1995Article
- Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.British journal of cancer · 1994Article
- Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha.Immunology · 1994Article
- The role of tumor necrosis factor receptors in cell signaling and the significance of soluble form levels in the serum.Surgery today · 1994Review
- Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity.Immunology · 1994Article
- Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.Clinical and experimental immunology · 1993Article
- The effect of tumour necrosis factor-alpha (TNF-alpha) muteins on human neutrophils in vitro.Mediators of inflammation · 1993Article
- Is the follicular dendritic cell a primarily stationary cell?Immunology · 1992Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature and location of cells responding to tumour necrosis factor-alpha (TNF-alpha) were investigated in situ by immunohistochemistry using monoclonal antibodies (mAb) directed against the p75 and p55 proteins of the TNF receptor. Receptor expression was found in the thymus and secondary lymphoid tissues. In the thymus the p75 receptor was confined to medullary lymphoblasts and dendritic cells, which co-stain with the Tac protein of the interleukin-2 (IL-2) receptor. In lymph nodes and other secondary lymphoid tissues, the p75 receptor was expressed on activated lymphocytes and interdigitating reticulum cells of the T-cell area, whereas the p55 receptor was confined to the germinal centre dendritic reticulum cells (DRC), which is the main site of TNF-alpha production. TNF receptor (TNFR) proteins were up-regulated in reactive hyperplasia together with increased TNF-alpha expression. Surprisingly, no TNFR was detectable on non-lymphoid tissues. The species specificity of these TNFR antibodies was high: whereas the antibodies cross-reacted with epitopes in non-human primates, no immunoreactivity was detected in lower animal species, e.g. dog, rabbit and rodents. The data presented suggest that TNF-alpha, which is produced by germinal centre DRC, might regulate an in vivo immune response through autocrine and paracrine pathways, e.g. through the p55 and p75 receptor proteins, which are expressed at different sites of the lymphoid tissue.
Indexed as
Identifiers
1663076PMC1384638W126653784What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.