ArticleImmunology2006
Evolutionary conservation of neuropeptide expression in the thymus of different species.
Article in Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Regulation and Function of Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): The Role of the SRIF System in Macrophage Regulation.International journal of molecular sciences · 2025Review
- Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives.ACS chemical neuroscience · 2025Review
- Intrathymic somatotropic circuitry: consequences upon thymus involution.Frontiers in immunology · 2023Review
- Neurotransmitters Modulate Intrathymic T-cell Development.Frontiers in cell and developmental biology · 2021Review
- RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development.International journal of genomics · 2019Article
- Application of Zebrafish Models in Inflammatory Bowel Disease.Frontiers in immunology · 2017Review
- Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.Oncotarget · 2016Article
- The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.Oncotarget · 2016Article
- Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish.PloS one · 2013Article
- NPY and stress 30 years later: the peripheral view.Cellular and molecular neurobiology · 2012Review
- Calcitonin gene-related peptide inhibits chemokine production by human dermal microvascular endothelial cells.Brain, behavior, and immunity · 2011Article
- Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus.Cell and tissue research · 2009Article
- Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age.F1000 biology reports · 2009Article
- Article
- Immunosenescence: emerging challenges for an ageing population.Immunology · 2007Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that the immune and neuroendocrine systems cross talk by sharing ligands and receptors. Hormones and neuropeptides produced by the neuroendocrine system often modulate the function of lymphoid organs and immune cells. We have previously reported the intrathymic expression of somatostatin (SOM) in the mouse and that several neuropeptides, most notably calcitonin-gene-related peptide (CGRP), neuropeptide Y (NPY), SOM and substance P (SP), can modulate thymocyte development. However, little is known about the intrathymic expression of these neuropeptides either in the mouse or in other species. Moreover, a comparative analysis of the expression of these molecules would highlight the evolutionary importance of intrathymic neuroendocrine interactions in T-cell development. We have studied the expression of different neuropeptides in the thymus of zebrafish, Xenopus, avians, rodent, porcine, equine and human by immunohistochemistry and reverse transcription-polymerase chain reaction. We found that CGRP, NPY, SOM, SP and vasointestinal polypeptide (VIP) are expressed in the thymus of all species investigated. The thymic location of many of these neuropeptides was conserved and appears to be within the stromal compartments. Interestingly, in the avian thymus the expression of CGRP, SOM and SP appears to change depending on the age of the tissue. These findings suggest that neuropeptides may play an important role in T-cell development and provide further evidence of cross talk between the immune and neuroendocrine systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.