ArticleThe Journal of comparative neurology2006
N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat.
Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity.Cellular and molecular neurobiology · 2023Article
- Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.Nature communications · 2019Article
- The metabolic role of vagal afferent innervation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons.Physiology & behavior · 2018Article
- Central inhibition of initiation of swallowing by systemic administration of diazepam and baclofen in anaesthetized rats.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.Brain research · 2015Article
- NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Vagal afferent NMDA receptors modulate CCK-induced reduction of food intake through synapsin I phosphorylation in adult male rats.Endocrinology · 2013Article
- Astrocytes in the hindbrain detect glucoprivation and regulate gastric motility.Autonomic neuroscience : basic & clinical · 2013Review
- CCK-induced reduction of food intake and hindbrain MAPK signaling are mediated by NMDA receptor activation.Endocrinology · 2012Article
- A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals.Physiology & behavior · 2011Review
- Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Neural proliferation and restoration of neurochemical phenotypes and compromised functions following capsaicin-induced neuronal damage in the nodose ganglion of the adult rat.Frontiers in neuroscience · 2011Article
- Glutamate- and GABA-mediated neuron-satellite cell interaction in nodose ganglia as revealed by intracellular calcium imaging.Histochemistry and cell biology · 2010Article
- Proteinase-activated receptors in the nucleus of the solitary tract: evidence for glial-neural interactions in autonomic control of the stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2008Article
- Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats.Neuroscience · 2008Article
- Coupling of neuronal nitric oxide synthase to NMDA receptors via postsynaptic density-95 depends on estrogen and contributes to the central control of adult female reproduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Most vagal afferent neurons in rat nodose ganglia express mRNA coding for the NR1 subunit of the heteromeric N-methyl-D-aspartate (NMDA) receptor ion channel. NMDA receptor subunit immunoreactivity has been detected on axon terminals of vagal afferents in the dorsal hindbrain, suggesting a role for presynaptic NMDA receptors in viscerosensory function. Although NMDA receptor subunits (NR1, NR2B, NR2C, and NR2D) have been linked to distinct neuronal populations in the brain, the NMDA receptor subunit phenotype of vagal afferent neurons has not been determined. Therefore, we examined NMDA receptor subunit (NR1, NR2B, NR2C, and NR2D) immunoreactivity in vagal afferent neurons. We found that, although the left nodose contained significantly more neurons (7,603), than the right (5,978), the proportions of NMDA subunits expressed in the left and right nodose ganglia were not significantly different. Immunoreactivity for NMDA NR1 subunit was present in 92.3% of all nodose neurons. NR2B immunoreactivity was present in 56.7% of neurons; NR2C-expressing nodose neurons made up 49.4% of the total population; NR2D subunit immunoreactivity was observed in just 13.5% of all nodose neurons. Double labeling revealed that 30.2% of nodose neurons expressed immunoreactivity to both NR2B and NR2C, whereas NR2B and NR2D immunoreactivities were colocalized in 11.5% of nodose neurons. NR2C immunoreactivity colocalized with NR2D in 13.1% of nodose neurons. Our results indicate that most vagal afferent neurons express NMDA receptor ion channels composed of NR1, NR2B, and NR2C subunits and that a minority phenotype that expresses NR2D also expresses NR1, NR2B, and NR2C.
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