ArticleThe EMBO journal2006
The length of the transcript encoded from the Kcnq1ot1 antisense promoter determines the degree of silencing.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Natural antisense transcript Nat9a suppresses Scn9a (NaScientific reports · 2026Article
- Exploring the enigma: history, present, and future of long non-coding RNAs in cancer.Discover oncology · 2024Review
- The control of polycomb repressive complexes by long noncoding RNAs.Wiley interdisciplinary reviews. RNA · 2021Review
- The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactome.Nucleic acids research · 2021Article
- Long Noncoding RNAs: An Overview.Methods in molecular biology (Clifton, N.J.) · 2021Article
- LncRNAs and PRC2: Coupled Partners in Embryonic Stem Cells.Epigenomes · 2019Review
- Convergence in LINE-1 nucleotide variations can benefit redundantly forming triplexes with lncRNA in mammalian X-chromosome inactivation.Mobile DNA · 2019Article
- The Big Entity of New RNA World: Long Non-Coding RNAs in Microvascular Complications of Diabetes.Frontiers in endocrinology · 2018Review
- A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.Scientific reports · 2017Article
- Long non-coding RNAs: Mechanism of action and functional utility.Non-coding RNA research · 2016Review
- Associating schizophrenia, long non-coding RNAs and neurostructural dynamics.Frontiers in molecular neuroscience · 2015Review
- Transcriptional silencing by polycomb-group proteins.Cold Spring Harbor perspectives in biology · 2014Review
- Emerging epigenetic mechanisms of long non-coding RNAs.Neuroscience · 2014Review
- Review
- The functional role of long non-coding RNAs and epigenetics.Biological procedures online · 2014Review
- An emerging role for long non-coding RNA dysregulation in neurological disorders.International journal of molecular sciences · 2013Review
- Long noncoding RNAs: past, present, and future.Genetics · 2013Review
- Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.American journal of translational research · 2012Article
- Shaping the Genome with Non-Coding RNAs.Current genomics · 2011Article
- Regulated antisense transcription controls expression of cell-type-specific genes in yeast.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying mechanisms linking antisense RNA, chromatin architecture and gene expression have not been fully elucidated. Here we show that long transcripts encoded from the Kcnq1ot1 antisense promoter silence the flanking genes more efficiently than short antisense transcripts. Interestingly, the antisense RNA-mediated deposition of inactive chromatin-specific histone modifications was higher with the longer antisense transcripts than with the shorter antisense transcripts. The kinetic studies of expression and chromatin remodeling of overlapping and nonoverlapping genes in response to antisense transcription revealed that the overlapping gene was rapidly silenced due to decrease in the occupancy of basal transcription machinery and simultaneous enrichment of its promoter with inactive chromatin modifications. The nonoverlapping gene, initially enriched with histone modifications specific to active chromatin, was subsequently silenced. Surprisingly, the flanking sequences were initially enriched with H3K9 monomethylation, as compared to di- and trimethylation, with a subsequent shift to trimethylated H3K9 enrichment. Our data provide a new perspective into antisense RNA-mediated gene silencing, and, more importantly, provide an explanation for why the antisense transcripts encoded from imprinting control regions are of significant length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.