ArticleThe EMBO journal2006
Opaque cells signal white cells to form biofilms in Candida albicans.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- The genotoxic stress-inducible geneVirulence · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Glucose depletion enables Candida albicans mating independently of the epigenetic white-opaque switch.Nature communications · 2023Article
- FungiExpresZ: an intuitive package for fungal gene expression data analysis, visualization and discovery.Briefings in bioinformatics · 2023Article
- α-Pheromone Precursor Protein Foc4-PP1 Is Essential for the Full Virulence ofJournal of fungi (Basel, Switzerland) · 2023Article
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Developing novel antifungals: lessons from G protein-coupled receptors.Trends in pharmacological sciences · 2023Review
- Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.The Journal of cell biology · 2022Article
- Role of themBio · 2021Article
- Bend or break: how biochemically versatile molecules enable metabolic division of labor in clonal microbial communities.Genetics · 2021Review
- Cation Transporters ofBiomolecules · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- Genetic regulation of the development of mating projections inEmerging microbes & infections · 2020Article
- Mating yeast cells use an intrinsic polarity site to assemble a pheromone-gradient tracking machine.The Journal of cell biology · 2019Article
- High throughput gene expression profiling of yeast colonies with microgel-culture Drop-seq.Lab on a chip · 2019Article
- Article
- In Vitro Culturing and Screening of Candida albicans Biofilms.Current protocols in microbiology · 2018Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Upon homozygosis from a/alpha to a/a or alpha/alpha, Candida albicans must still switch from the 'white' to 'opaque' phenotype to mate. It was, therefore, surprising to discover that pheromone selectively upregulated mating-associated genes in mating-incompetent white cells without causing G1 arrest or shmoo formation. White cells, like opaque cells, possess pheromone receptors, although their distribution and redistribution upon pheromone treatment differ between the two cell types. In speculating about the possible role of the white cell pheromone response, it is hypothesized that in overlapping white a/a and alpha/alpha populations in nature, rare opaque cells, through the release of pheromone, signal majority white cells of opposite mating type to form a biofilm that facilitates mating. In support of this hypothesis, it is demonstrated that pheromone induces cohesiveness between white cells, minority opaque cells increase two-fold the thickness of majority white cell biofilms, and majority white cell biofilms facilitate minority opaque cell chemotropism. These results reveal a novel form of communication between switch phenotypes, analogous to the inductive events during embryogenesis in higher eukaryotes.
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Registered trials
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