Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2006
Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis.
Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 8 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- The Changing Landscape of Chronic Pancreatitis Research Trajectories Over Two Decades: A Global Meta-Analysis Using MeSH Terms.United European gastroenterology journal · 2026Pooled it
- Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPGHAN Pancreas Committee and ESPGHAN Cystic Fibrosis/Pancreas Working Group.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Antioxidant therapy in acute, chronic and post-endoscopic retrograde cholangiopancreatography pancreatitis: An updated systematic review and meta-analysis.World journal of gastroenterology · 2015Pooled it
- Antioxidants for pain in chronic pancreatitis.The Cochrane database of systematic reviews · 2014Pooled it
- Treatment options in painful chronic pancreatitis: a systematic review.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014Pooled it
- Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: a systematic review.World journal of gastroenterology · 2014Pooled it
- Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review.World journal of gastroenterology · 2009Pooled it
- Antioxidant supplements for preventing gastrointestinal cancers.The Cochrane database of systematic reviews · 2008Pooled it
- Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial.Digestive diseases and sciences · 2021Trial
- Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy.World journal of gastroenterology · 2010Trial
- Systematic Approach to Treatment of Chronic Pancreatitis.Gastroenterology & hepatology · 2026Article
- Melatonin Improves Quality of Life, Oxidative Stress, and Cardiovascular Function in Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Article
- Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis-A Literature Review.Biomolecules · 2024Review
- Management of chronic pancreatitis: recent advances and future prospects.Therapeutic advances in gastroenterology · 2024Review
- Yttrium Oxide Nanoparticles Attenuate L-Arginine Induced Chronic Pancreatitis.Biological trace element research · 2023Article
- Efficacy and Predictors of Pain Response to Combined Antioxidants in Children with Chronic Pancreatitis.Digestive diseases and sciences · 2023Article
- Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Antioxidant Therapy in Pancreatitis.Antioxidants (Basel, Switzerland) · 2021Review
- Systematic review and meta-analysis: Is there any role for antioxidant therapy for pain in chronic pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels.Current neuropharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic pancreatitis (CP) typically suffer intractable abdominal pain that is resistant to most analgesic strategies. Recent research indicates that the pain of CP may be in part due to oxygen free radical induced pancreatic damage. Using a randomized, double-blind, placebo-controlled crossover trial, we evaluated the efficacy of a combined antioxidant preparation in the management of CP. Patients with confirmed chronic pancreatitis (N = 36) were randomized to receive treatment with either Antox, which contains the antioxidants selenium, betacarotene, L-methionine, and vitamins C and E, or placebo for 10 weeks. Each group of patients then switched to receive the alternative treatment for a further 10 weeks. Markers of antioxidant status were measured by blood sampling, whereas quality of life and pain were assessed using the SF-36 questionnaire. Nineteen patients completed the full 20 weeks of treatment. Treatment with Antox was associated with significant improvements in quality of life in terms of pain (+17 antioxidant vs. -7 placebo), physical (+9 vs. -3) and social functioning (+8 vs. -7), and general health perception (+10 vs. -3). We conclude that treatment with antioxidants may improve quality of life and reduce pain in patients suffering from chronic pancreatitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.