ArticleExperimental eye research2006
Functional abnormalities in the retinal pigment epithelium of CFTR mutant mice.
Article in Experimental eye research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Ion channels research in hPSC-RPE cells: bridging benchwork to clinical applications.Journal of translational medicine · 2024Review
- Ocular Changes in Cystic Fibrosis: A Review.International journal of molecular sciences · 2024Review
- Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.Journal of visualized experiments : JoVE · 2020Article
- Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse Retina.Investigative ophthalmology & visual science · 2016Article
- Myosin 6 is required for iris development and normal function of the outer retina.Investigative ophthalmology & visual science · 2013Article
- Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.American journal of physiology. Cell physiology · 2012Article
- Bestrophins and retinopathies.Pflugers Archiv : European journal of physiology · 2010Review
- Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.Journal of neurophysiology · 2010Article
- Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.Investigative ophthalmology & visual science · 2010Article
- Functional roles of bestrophins in ocular epithelia.Progress in retinal and eye research · 2009Review
- Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE.Purinergic signalling · 2008Article
- Dependence of cAMP meditated increases in Cl- and HCO(3)- permeability on CFTR in bovine corneal endothelial cells.Experimental eye research · 2008Article
- Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.Investigative ophthalmology & visual science · 2008Article
- Voltage-dependent calcium channel CaV1.3 subunits regulate the light peak of the electroretinogram.Journal of neurophysiology · 2007Article
- Light and alcohol evoked electro-oculograms in cystic fibrosis.Documenta ophthalmologica. Advances in ophthalmology · 2006Article
- The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1).The Journal of general physiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
In response to light, the mouse retinal pigment epithelium (RPE) generates a series of slow changes in potential that are referred to as the c-wave, fast oscillation (FO) and light peak (LP) of the electroretinogram (ERG). While the FO is known to reflect a Cl(-) conductance generated at the basal membrane of the RPE, the specific channel (s) underlying this potential has not been identified. In the present study we examined two strains of mice with cftr mutations to define the contribution that cystic fibrosis transmembrane regulator (CFTR)-mediated Cl(-) conductance makes to the mouse ERG. Responses obtained from cftr(Delta508/Delta508) mice exhibited an overall reduction in all components generated by the RPE in response to light without alteration of the luminance response function. Responses obtained from cftr(-/-) mice were also reduced in amplitude. These results illustrate the usefulness of ERG analysis of mice deficient in ion channels that are expressed in the RPE, and indicate that CFTR contributes to the generation of RPE-driven ERG components, but that it is not the sole generator of any one of these components.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.