Evidence map›Paper›PMID 16626648›Full record

ReviewBrain research2006

Studying inner ear protein-protein interactions using FRET and FLIM.

Richard Hallworth, Benjamin Currall, Michael G Nichols, Xudong Wu, Jian Zuo

Abstract readReview
In one paragraph

Review in Brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Large Scale Chemical Cross-linking Mass Spectrometry Perspectives.Journal of proteomics & bioinformatics · 2013
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richard HallworthDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA. hallw@creighton.edu
Benjamin Currall
Michael G Nichols
Xudong Wu
Jian Zuo

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9M
GENETIC ANALYSIS OF MAMMALIAN HEARING SENSITIVITYR01DC006471 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZUO, JIAN · 2004 to 2013
$3.5M
CONSTRUCTION OF RESEARCH FACILITYC06RR017417 · NCRR · CREIGHTON UNIVERSITY · PI WILSON, M. ROY · 2002 to 2002
$2.0M
THE MECHANISM OF OUTER HAIR CELL MOTILITYR01DC002053 · NIDCD · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI HALLWORTH, RICHARD JOHN · 2000 to 2004
$1.0M
MECHANISM OF OUTER HAIR CELL MOTILITYR29DC002053 · NIDCD · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI HALLWORTH, RICHARD JOHN · 1993 to 1997
–
NCI NIH HHS CA21765NCI NIH HHS P30 CA021765NCRR NIH HHS C06 RR017417NCRR NIH HHS RR17417-01NIDCD NIH HHS DC 02053NIDCD NIH HHS DC 06471NIDCD NIH HHS R01 DC002053NIDCD NIH HHS R01 DC006471NIDCD NIH HHS R29 DC002053
6 · The paper itself

Abstract

Molecular genetic studies of the inner ear have recently revealed a large number of previously undescribed proteins, but their functions remain unclear. Optical methods such as FRET and FLIM are just beginning to be applied to the study of functional interactions between novel inner ear proteins. This review discusses the various methods for employing FRET and FLIM in protein-protein interaction studies, their advantages and pitfalls, with examples drawn from inner ear studies.

Indexed as

Motion PicturesAnimalsDiagnostic ImagingEar, InnerFluorescence Resonance Energy TransferHumansProtein BindingProtein FoldingProteinsProteins

Identifiers

PMID16626648
PMCPMC1992439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.