ArticleBMC neuroscience2006
The photocurrent response of human cones is fast and monophasic.
Article in BMC neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Optical imaging of human cone photoreceptors directly following the capture of light.PloS one · 2013Trial
- Using Virtual Patients to Predict Perceptual Outcomes for Optogenetic Sight Recovery Technologies.Research square · 2026Article
- Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.bioRxiv : the preprint server for biology · 2026Article
- Using Virtual Patients to Predict Perceptual Outcomes for Optogenetic Sight Recovery Technologies.bioRxiv : the preprint server for biology · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- Dyschromatopsia: a comprehensive analysis of mechanisms and cutting-edge treatments for color vision deficiency.Frontiers in neuroscience · 2024Review
- Assessment of digital light processing (DLP) projector stimulators for visual electrophysiology.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Human cone elongation responses can be explained by photoactivated cone opsin and membrane swelling and osmotic response to phosphate produced by RGS9-catalyzed GTPase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Dark Adaptation and Its Role in Age-Related Macular Degeneration.Journal of clinical medicine · 2022Review
- The electroretinogram in the genomics era: outer retinal disorders.Eye (London, England) · 2021Review
- Networking retinomorphic sensor with memristive crossbar for brain-inspired visual perception.National science review · 2021Article
- The optoretinogram reveals the primary steps of phototransduction in the living human eye.Science advances · 2020Article
- Mobile Eye Tracking During Real-World Night Driving: A Selective Review of Findings and Recommendations for Future Research.Journal of eye movement research · 2017Article
- Why rods and cones?Eye (London, England) · 2016Review
- Retinal Lateral Inhibition Provides the Biological Basis of Long-Range Spatial Induction.PloS one · 2016Article
- Article
- Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity.The Journal of biological chemistry · 2015Article
- Activation and quenching of the phototransduction cascade in retinal cones as inferred from electrophysiology and mathematical modeling.Molecular vision · 2015Article
- Evaluating letter recognition, flicker fusion, and the Talbot-Plateau law using microsecond-duration flashes.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe precise form of the light response of human cone photoreceptors in vivo has not been established with certainty. To investigate the response shape we compare the predictions of a recent model of transduction in primate cone photoreceptors with measurements extracted from human cones using the paired-flash electroretinogram method. As a check, we also compare the predictions with previous single-cell measurements of ground squirrel cone responses.
resultsThe predictions of the model provide a good description of the measurements, using values of parameters within the range previously determined for primate retina. The dim-flash response peaks in about 20 ms, and flash responses at all intensities are essentially monophasic. Three time constants in the model are extremely short: the two time constants for inactivation (of visual pigment and of transducin/phosphodiesterase) are around 3 and 10 ms, and the time constant for calcium equilibration lies in the same range.
conclusionThe close correspondence between experiment and theory, using parameters previously derived for recordings from macaque retina, supports the notion that the electroretinogram approach and the modelling approach both provide an accurate estimate of the cone photoresponse in the living human eye. For reasons that remain unclear, the responses of isolated photoreceptors from the macaque retina, recorded previously using the suction pipette method, are considerably slower than found here, and display biphasic kinetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.