Evidence map›Paper›PMID 16625643›Full record

SynthesisThe Cochrane database of systematic reviews2006

Leukotriene receptor antagonist for prolonged non-specific cough in children.

A B Chang, D Winter, J P Acworth

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Analysis of the Literature on Chronic Cough in Children.The open respiratory medicine journal · 2017
    Review
  4. Article
  5. Cough hypersensitivity as a neuro-immune interaction.Clinical and translational allergy · 2015
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

A B ChangRoyal Children's Hospital, Respiratory Medicine, Herston Road, Herston, Brisbane, Queensland, Australia, 4029. Anne_B_Chang@health.qld.gov.au
D Winter
J P Acworth
Royal Children's Hospital · AURoyal Brisbane and Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including a variety of asthma medications. The leukotriene pathway is reported to be involved in the sensory (neurogenic) pathway, which is a mechanism thought to be involved in the pathogenesis of chronic cough.

objectivesTo evaluate the effectiveness of leukotriene receptor antagonist (LTRA) in treating children with prolonged non-specific cough. SEARCH STRATEGY: The Cochrane Register of Controlled Trials (CENTRAL), the Cochrane Airways Group Specialised Register, MEDLINE and EMBASE databases were searched by the Cochrane Airways Group. The latest searches were carried out in September 2005. SELECTION CRITERIA: All randomised controlled trials comparing LTRA with a placebo medication in children with non-specific cough. DATA COLLECTION AND ANALYSIS: Results of searches were reviewed against pre-determined criteria for inclusion. One eligible trial was identified but no data was available for analysis. It was not possible to separate results from children with non-specific cough from those without. MAIN

resultsThere was no significant difference in all study endpoints between the montelukast and placebo groups (total N=256). AUTHORS'

conclusionsWith the lack of evidence, the routine use of LRTA in treating children with non-specific cough cannot be recommended.

Indexed as

AcetatesChildCoughCyclopropanesHumansLeukotriene AntagonistsQuinolinesSulfidesAcetatesCyclopropanesLeukotriene AntagonistsmontelukastQuinolinesSulfides

Identifiers

PMID16625643
PMCPMC8896275
OpenAlexW2171679083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.