ArticleMolecular genetics and genomics : MGG2006
Global transcriptional analysis of Methanosarcina mazei strain Gö1 under different nitrogen availabilities.
Article in Molecular genetics and genomics : MGG, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Quantitative analysis of amino acid excretion by Methanothermobacter marburgensis under NScientific reports · 2025Article
- Functional insights into Solo-Cas4 inmicroLife · 2025Article
- Uncovering the small proteome of Methanosarcina mazei using Ribo-seq and peptidomics under different nitrogen conditions.Nature communications · 2024Article
- Newly Established Genetic System for Functional Analysis of MetSV.International journal of molecular sciences · 2023Article
- Article
- Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The potential for polyphosphate metabolism in Archaea and anaerobic polyphosphate formation in Methanosarcina mazei.Scientific reports · 2019Article
- Global Transcriptional Programs in Archaea Share Features with the Eukaryotic Environmental Stress Response.Journal of molecular biology · 2019Review
- Methylamine-specific methyltransferase paralogs in Methanosarcina are functionally distinct despite frequent gene conversion.The ISME journal · 2019Article
- Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains.Journal of virology · 2017Article
- sRNARNA biology · 2017Article
- Horizontal gene transfer drives the evolution of Rh50 permeases in prokaryotes.BMC evolutionary biology · 2017Article
- Horizontal gene transfer and genome evolution in Methanosarcina.BMC evolutionary biology · 2015Article
- Towards a computational model of a methane producing archaeum.Archaea (Vancouver, B.C.) · 2014Article
- Small regulatory RNAs in Archaea.RNA biology · 2014Review
- A functional approach to uncover the low-temperature adaptation strategies of the archaeon Methanosarcina barkeri.Applied and environmental microbiology · 2013Article
- Two CRISPR-Cas systems in Methanosarcina mazei strain Gö1 display common processing features despite belonging to different types I and III.RNA biology · 2013Article
- Contribution of transcriptomics to systems-level understanding of methanogenic Archaea.Archaea (Vancouver, B.C.) · 2013Review
- An archaeal sRNA targeting cis- and trans-encoded mRNAs via two distinct domains.Nucleic acids research · 2012Article
- Global transcriptomic and proteomic responses of Dehalococcoides ethenogenes strain 195 to fixed nitrogen limitation.Applied and environmental microbiology · 2012Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain archaeal species can fix molecular nitrogen under nitrogen limiting conditions although little is known about this process at either the genetic or molecular level. To address this on a genome-wide scale, transcriptional analysis was performed on the model methanogen Methanosarcina mazei strain Gö1 using DNA-microarrays. The genomic expression patterns for cells grown under nitrogen fixing conditions versus nitrogen sufficiency (10 mM ammonium) revealed that approximately 5% of all genes are differentially expressed. Besides a small set of genes previously known to be up-regulated under nitrogen limitation, 14 additional genes involved in nitrogen metabolism were identified plus 10 genes encoding potential transcriptional regulators, 13 genes involved in carbon metabolism, 3 genes in general stress response, 8 putative transporter genes, and an additional 21 genes with unknown function. Quantitative reverse transcriptase PCR experiments confirmed the differential expression of a subset of these genes. Promoter analysis revealed a palindromic DNA motif centered nearby the transcriptional start point for several genes up-regulated under nitrogen limitation. A bioinformatics study demonstrated the presence of this motif in the up-stream region of 52 genes genome-wide, the majority of which showed nitrogen dependent differential transcription. We therefore hypothesize that this DNA element is involved in nitrogen control in M. mazei where it may act as a binding site for a regulatory protein.
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