ArticleGenes and immunity2006
Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures.Frontiers in immunology · 2021Pooled it
- Mining Complex Genetic Patterns Conferring Multiple Sclerosis Risk.International journal of environmental research and public health · 2021Article
- A Framework for Efficient N-Way Interaction Testing in Case/Control Studies With Categorical Data.IEEE open journal of engineering in medicine and biology · 2021Article
- Association ofFrontiers in genetics · 2021Article
- Network graph analysis of gene-gene interactions in genome-wide association study data.Genomics & informatics · 2012Article
- Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population.Journal of biomedical science · 2012Article
- Review
- The genetics of alcohol dependence: advancing towards systems-based approaches.Drug and alcohol dependence · 2012Review
- A Polygenic Approach to the Study of Polygenic Diseases.Acta naturae · 2012Article
- Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.Genome medicine · 2011Article
- The effect of retrospective sampling on estimates of prediction error for multifactor dimensionality reduction.Annals of human genetics · 2011Article
- A comparison of multifactor dimensionality reduction and L1-penalized regression to identify gene-gene interactions in genetic association studies.Statistical applications in genetics and molecular biology · 2011Article
- A comparison of internal validation techniques for multifactor dimensionality reduction.BMC bioinformatics · 2010Article
- Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients.Psychiatry investigation · 2010Article
- A gene-based method for detecting gene-gene co-association in a case-control association study.European journal of human genetics : EJHG · 2010Article
- Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models.Human heredity · 2009Article
- Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction.BMC bioinformatics · 2008Article
- Synergistic effect of the genetic polymorphisms of the renin-angiotensin-aldosterone system on high-altitude pulmonary edema: a study from Qinghai-Tibet altitude.European journal of epidemiology · 2008Article
- DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans.Genes and immunity · 2007Article
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.Nature genetics · 2007Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal pathology, and progressive neurological dysfunction. Multiple sclerosis exhibits many of the characteristics that distinguish complex genetic disorders including polygenic inheritance and environmental exposure risks. Here, we used a highly efficient multilocus genotyping assay representing variation in 34 genes associated with inflammatory pathways to explore gene-gene interactions and disease susceptibility in a well-characterized African-American case-control MS data set. We applied the multifactor dimensionality reduction (MDR) test to detect epistasis, and identified single-IL4R(Q576R)- and three-IL4R(Q576R), IL5RA(-80), CD14(-260)- locus association models that predict MS risk with 75-76% accuracy (P<0.01). These results demonstrate the importance of exploring both main effects and gene-gene interactions in the study of complex diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.