ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Ambient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature.Cell communication and signaling : CCS · 2026Article
- Neuroimmune regulation of the prefrontal cortex tetrapartite synapse.Neuropharmacology · 2025Review
- GABAergic integration of transient and persistent neurons in the developing mouse somatosensory cortex.Frontiers in cellular neuroscience · 2025Article
- Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing.Nature communications · 2024Article
- Tonic activation of GABAFrontiers in synaptic neuroscience · 2023Article
- GABA Release from Astrocytes in Health and Disease.International journal of molecular sciences · 2022Review
- Keeping the Balance: GABABrain sciences · 2022Review
- Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.Cells · 2021Review
- Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective.International journal of molecular sciences · 2019Review
- Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind.Brain research · 2018Review
- Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex.Neuroscience bulletin · 2018Article
- Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity.Nature communications · 2015Article
- Taurine activates GABAergic networks in the neocortex of immature mice.Frontiers in cellular neuroscience · 2014Article
- Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation.The Journal of physiology · 2013Article
- γ-Aminobutyric acid (GABA) homeostasis regulates pollen germination and polarized growth in Picea wilsonii.Planta · 2013Article
- Anion transport and GABA signaling.Frontiers in cellular neuroscience · 2013Review
- Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.The Journal of physiology · 2013Article
- Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Emerging neurotrophic role of GABAB receptors in neuronal circuit development.Frontiers in cellular neuroscience · 2013Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At early stages of brain development, GABA plays a dual role. It fulfills important trophic functions and provides a major excitatory drive for the immature neuronal network. Here, we investigated whether GABA itself can limit the strength of excitatory GABAergic synapses on Cajal-Retzius (CR) cells in sagittal slices from the mouse visual cortex. (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid (CGP55845), a specific GABAB receptor (GABABR) blocker, increased the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but did not affect mIPSC amplitudes or kinetics. CGP55845 significantly increased evoked IPSC (eIPSC) amplitudes and decreased the paired-pulse ratio (PPR). Baclofen, a specific GABABR agonist, produced opposite effects. The size of the readily releasable pool was not affected by these GABABR modulators. The same CGP55845 actions were observed at physiological temperatures, but they were abolished after glutamate decarboxylase block with 3-mercaptopropionic acid (3-MP). These results indicate that presynaptic GABABRs dynamically regulate GABA release probability. SNAP-5114, a specific GABA transporter-2/3 (GAT-2/3) blocker, enhanced mIPSC frequencies, decreased PPR, and increased eIPSC amplitudes without changing eIPSC kinetics. These effects were blocked by CGP55845 and 3-MP. NO-711, a specific GAT-1 blocker, prolonged eIPSC decay and decreased eIPSC/mIPSC amplitudes. These NO-711-mediated effects were not sensitive to CGP55845 and 3-MP. We conclude that the strength of GABAergic inputs to CR cells is constrained by GABABRs that are persistently activated by ambient GABA. The latter is also provided by GAT-2/3 operating in the reversed mode. Presynaptic GAT-1 functions in the uptake mode and possibly provides GABA for presynaptic vesicle filling.
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