ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Light-induced changes in spike synchronization between coupled ON direction selective ganglion cells in the mammalian retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice.Investigative ophthalmology & visual science · 2023Article
- Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
- Modulation of the zebrafish optokinetic reflex by pharmacologic agents targeting GABANeuroscience letters · 2018Article
- Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells.Scientific reports · 2018Article
- Heterocellular Coupling Between Amacrine Cells and Ganglion Cells.Frontiers in neural circuits · 2018Article
- Electrical synapses convey orientation selectivity in the mouse retina.Nature communications · 2017Article
- Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Article
- Coding Properties of Mouse Retinal Ganglion Cells with Dual-Peak Patterns with Respect to Stimulus Intervals.Frontiers in computational neuroscience · 2016Article
- GABAergic neurotransmission and retinal ganglion cell function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Inner retinal inhibition shapes the receptive field of retinal ganglion cells in primate.The Journal of physiology · 2014Article
- Shape recognition elicited by microsecond flashes is not based on photon quantity.i-Perception · 2014Article
- Attractor dynamics in local neuronal networks.Frontiers in neural circuits · 2014Article
- Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Stimulus discrimination via responses of retinal ganglion cells and dopamine-dependent modulation.Neuroscience bulletin · 2013Article
- Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments.Journal of computational neuroscience · 2013Article
- Gap junctions are essential for generating the correlated spike activity of neighboring retinal ganglion cells.PloS one · 2013Article
- Adaptive neural information processing with dynamical electrical synapses.Frontiers in computational neuroscience · 2013Article
- Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection.Journal of neuroscience methods · 2012Article
- Direction selectivity in the retina: symmetry and asymmetry in structure and function.Nature reviews. Neuroscience · 2012Review
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7 authors.
Funding
Abstract
Although electrical coupling via gap junctions is prevalent among ganglion cells in the vertebrate retina, there have been few direct studies of their influence on the light-evoked signaling of these cells. Here, we describe the pattern and function of coupling between the ON direction selective (DS) ganglion cells, a unique subtype whose signals are transmitted to the accessory optic system (AOS) where they initiate the optokinetic response. ON DS cells are coupled indirectly via gap junctions made with a subtype of polyaxonal amacrine cell. This coupling underlies synchronization of the spontaneous and light-evoked spike activity of neighboring ON DS cells. However, we find that ON DS cell pairs show robust synchrony for all directions of stimulus movement, except for the null direction. Null stimulus movement evokes a GABAergic inhibition that temporally shifts firing of ON DS cell neighbors, resulting in a desynchronization of spike activity. Thus, detection of null stimulus movement appears key to the direction selectivity of ON DS cells, evoking both an attenuation of spike frequency and a desynchronization of neighbors. We posit that active desynchronization reduces summation of synaptic potentials at target AOS cells and thus provides a secondary mechanism by which ON DS cell ensembles can signal direction of stimulus motion to the brain.
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