ArticleGenetics2006
On locating multiple interacting quantitative trait loci in intercross designs.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Potential application of elastic nets for shared polygenicity detection with adapted threshold selection.The international journal of biostatistics · 2023Article
- Genetic Bases of Complex Traits: From Quantitative Trait Loci to Prediction.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Genetic architecture of male fertility restoration of Triticum timopheevii cytoplasm and fine-mapping of the major restorer locus Rf3 on chromosome 1B.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Effect of a rye dwarfing gene on plant height, heading stage, and Fusarium head blight in triticale (×Triticosecale Wittmack).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Fence Methods for Backcross Experiments.Journal of statistical computation and simulation · 2014Article
- Accession-specific modifiers act with ZWILLE/ARGONAUTE10 to maintain shoot meristem stem cells during embryogenesis in Arabidopsis.BMC genomics · 2013Article
- High-density genotyping: an overkill for QTL mapping? Lessons learned from a case study in maize and simulations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- New insights into the genetics of in vivo induction of maternal haploids, the backbone of doubled haploid technology in maize.Genetics · 2012Article
- Detection of epistatic interactions in association mapping populations: an example from tetraploid potato.Heredity · 2011Article
- Statistical analysis of genetic interactions.Genetics research · 2010Review
- A two-phase procedure for QTL mapping with regression models.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- High congruency of QTL positions for heterosis of grain yield in three crosses of maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Look before you leap: a new approach to mapping QTL.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Deviance Information Criterion (DIC) in Bayesian Multiple QTL Mapping.Computational statistics & data analysis · 2009Article
- Hierarchical generalized linear models for multiple quantitative trait locus mapping.Genetics · 2009Article
- A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis.Genetics · 2009Article
- Interactions between markers can be caused by the dominance effect of quantitative trait loci.Genetics · 2008Article
- Advances in Bayesian multiple quantitative trait loci mapping in experimental crosses.Heredity · 2008Review
- Inclusive composite interval mapping (ICIM) for digenic epistasis of quantitative traits in biparental populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2008Article
- Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits.Genetics · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
A modified version (mBIC) of the Bayesian Information Criterion (BIC) has been previously proposed for backcross designs to locate multiple interacting quantitative trait loci. In this article, we extend the method to intercross designs. We also propose two modifications of the mBIC. First we investigate a two-stage procedure in the spirit of empirical Bayes methods involving an adaptive (i.e., data-based) choice of the penalty. The purpose of the second modification is to increase the power of detecting epistasis effects at loci where main effects have already been detected. We investigate the proposed methods by computer simulations under a wide range of realistic genetic models, with nonequidistant marker spacings and missing data. In the case of large intermarker distances we use imputations according to Haley and Knott regression to reduce the distance between searched positions to not more than 10 cM. Haley and Knott regression is also used to handle missing data. The simulation study as well as real data analyses demonstrates good properties of the proposed method of QTL detection.
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