ArticleGenetics2006
Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.PLoS biology · 2024Article
- A force balance model for a cell size-dependent meiotic nuclear oscillation in fission yeast.EMBO reports · 2023Article
- Stochastic model of T cell repolarization during target elimination (II).Biophysical journal · 2022Article
- Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand.Molecular biology of the cell · 2022Article
- Spatiotemporal Dynamic Regulation of Organelles During Meiotic Development, Insights From Fungi.Frontiers in cell and developmental biology · 2022Article
- Overexpression of Mdm36 reveals Num1 foci that mediate dynein-dependent microtubule sliding in budding yeast.Journal of cell science · 2020Article
- Stochastic Model of T Cell Repolarization during Target Elimination I.Biophysical journal · 2020Article
- Cargo-Mediated Activation of Cytoplasmic DyneinFrontiers in cell and developmental biology · 2020Review
- Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.The Journal of cell biology · 2019Article
- A conserved mechanism for mitochondria-dependent dynein anchoring.Molecular biology of the cell · 2019Article
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport.PLoS genetics · 2017Article
- Fission yeast myosin I facilitates PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation.Chromosoma · 2016Review
- Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.The Journal of cell biology · 2015Article
- Dynein, microtubule and cargo: a ménage à trois.Biochemical Society transactions · 2013Review
- Transcriptional regulation of the copper transporter mfc1 in meiotic cells.Eukaryotic cell · 2013Article
- A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.The Journal of cell biology · 2012Article
- Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections?Trends in cell biology · 2009Review
- Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell.Cell motility and the cytoskeleton · 2009Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiotic prophase in the fission yeast Schizosaccharomyces pombe, the nucleus oscillates between the two ends of a cell. This oscillatory nuclear movement is important to promote accurate pairing of homologous chromosomes and requires cytoplasmic dynein. Dynein accumulates at the points where microtubule plus ends contact the cell cortex and generate a force to drive nuclear oscillation. However, it remains poorly understood how dynein associates with the cell cortex. Here we show that S. pombe Num1p functions as a cortical-anchoring factor for dynein. Num1p is expressed in a meiosis-specific manner and localized to the cell cortex through its C-terminal PH domain. The num1 deletion mutant shows microtubule dynamics comparable to that in the wild type. However, it lacks cortical accumulation of dynein and is defective in the nuclear oscillation as is the case for the dynein mutant. We also show that Num1p can recruit dynein independently of the CLIP-170 homolog Tip1p.
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