ArticleGenetics2006
A genetic test of the role of the maternal pronucleus in Wolbachia-induced cytoplasmic incompatibility in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility.Biochemical Society transactions · 2025Review
- Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality.Science (New York, N.Y.) · 2024Article
- The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-infected Aedes aegypti mosquitoes deployed for arbovirus control.PLoS biology · 2024Article
- Review
- Evolution-guided mutagenesis of the cytoplasmic incompatibility proteins: Identifying CifA's complex functional repertoire and new essential regions in CifB.PLoS pathogens · 2020Article
- Review
- TheeLife · 2019Article
- Article
- Quantitative methods for assessing local and bodywide contributions to Wolbachia titer in maternal germline cells of Drosophila.BMC microbiology · 2019Article
- Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila.PLoS genetics · 2019Article
- Endogenously imprinted genes in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2014Article
- Wolbachia: Can we save lives with a great pandemic?Trends in parasitology · 2013Review
- A new model and method for understanding Wolbachia-induced cytoplasmic incompatibility.PloS one · 2011Article
- Tissue and stage-specific distribution of Wolbachia in Brugia malayi.PLoS neglected tropical diseases · 2011Article
- Wolbachia-induced cytoplasmic incompatibility is associated with decreased Hira expression in male Drosophila.PloS one · 2011Article
- Wolbachia-mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus.PLoS pathogens · 2009Article
- Life and death of an influential passenger: Wolbachia and the evolution of CI-modifiers by their hosts.PloS one · 2009Article
- Multiple rescue factors within a Wolbachia strain.Genetics · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoplasmic incompatibility (CI) is a reproductive sterility found in arthropods that is caused by the endoparasitic bacteria Wolbachia. In CI, host progeny fail to develop during early embryogenesis if Wolbachia-infected males fertilize uninfected females. It is widely accepted that this lethality is caused by some unknown Wolbachia-induced modification of the paternal nuclear material in the host testes. However, the direct means by which this modification leads to early embryonic death are currently unresolved. Results from previous studies suggested that CI lethality occurs as a result of asynchrony in cell cycle timing between the paternal and maternal pronuclei. This hypothesis can be tested experimentally by the prediction that the Wolbachia-modified paternal pronucleus should support androgenetic development (i.e., from the paternal pronucleus only). Using specific mutations in Drosophila melanogaster that produce androgenetic progeny, we demonstrate that the Wolbachia-induced modification inhibits this type of development. This result suggests that CI occurs independently of the maternal pronucleus and argues against pronuclear asynchrony as the primary cause of CI lethality. We propose that CI occurs instead as the result of either a developmentally incompetent paternal pronucleus or asynchrony between the paternal pronucleus and the cell cycle of the egg cytoplasm.
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