ArticleGenetics2006
Estimating the contribution of mutation, recombination and gene conversion in the generation of haplotypic diversity.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Whole-genome resequencing of the wild barley diversity collection: a resource for identifying and exploiting genetic variation for cultivated barley improvement.G3 (Bethesda, Md.) · 2026Article
- Sodium azide mutagenesis induces a unique pattern of mutations.PLoS genetics · 2025Article
- Rural populations facilitated early SARS-CoV-2 evolution and transmission in Missouri, USA.Npj viruses · 2023Article
- Plant Genome Editing and the Relevance of Off-Target Changes.Plant physiology · 2020Article
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- The Role of Deleterious Substitutions in Crop Genomes.Molecular biology and evolution · 2016Article
- A Male-Specific Genetic Map of the Microcrustacean Daphnia pulex Based on Single-Sperm Whole-Genome Sequencing.Genetics · 2015Article
- Article
- Two genomic regions contribute disproportionately to geographic differentiation in wild barley.G3 (Bethesda, Md.) · 2014Article
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- Molecular evolution of human adenoviruses.Scientific reports · 2013Article
- Retention of agronomically important variation in germplasm core collections: implications for allele mining.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Fine-scale population recombination rates, hotspots, and correlates of recombination in the Medicago truncatula genome.Genome biology and evolution · 2012Article
- Crop genomics: advances and applications.Nature reviews. Genetics · 2011Review
- Rapid linkage disequilibrium decay in the Lr10 gene in wild emmer wheat (Triticum dicoccoides) populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Nucleotide diversity maps reveal variation in diversity among wheat genomes and chromosomes.BMC genomics · 2010Article
- The contribution of recombination to heterozygosity differs among plant evolutionary lineages and life-forms.BMC evolutionary biology · 2010Article
- Article
- Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes.Human mutation · 2008Article
- Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination occurs through both homologous crossing over and homologous gene conversion during meiosis. The contribution of recombination relative to mutation is expected to be dramatically reduced in inbreeding organisms. We report coalescent-based estimates of the recombination parameter (rho) relative to estimates of the mutation parameter (theta) for 18 genes from the highly self-fertilizing grass, wild barley, Hordeum vulgare ssp. spontaneum. Estimates of rho/theta are much greater than expected, with a mean rho/theta approximately 1.5, similar to estimates from outcrossing species. We also estimate rho with and without the contribution of gene conversion. Genotyping errors can mimic the effect of gene conversion, upwardly biasing estimates of the role of conversion. Thus we report a novel method for identifying genotyping errors in nucleotide sequence data sets. We show that there is evidence for gene conversion in many large nucleotide sequence data sets including our data that have been purged of all detectable sequencing errors and in data sets from Drosophila melanogaster, D. simulans, and Zea mays. In total, 13 of 27 loci show evidence of gene conversion. For these loci, gene conversion is estimated to contribute an average of twice as much as crossing over to total recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.