Evidence map›Paper›PMID 16623766›Full record

ReviewImmunological reviews2006

Microarray-based understanding of normal and malignant plasma cells.

John De Vos, Dirk Hose, Thierry Rème, Karin Tarte, Jérôme Moreaux, Karéne Mahtouk, Michel Jourdan, Hartmut Goldschmidt, Jean-François Rossi, Friedrich W Cremer and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

John De VosIRB, CHU Montpellier, Montpellier, France.
Dirk Hose
Thierry Rème
Karin Tarte
Jérôme Moreaux
Karéne Mahtouk
Michel Jourdan
Hartmut Goldschmidt
Jean-François Rossi
Friedrich W Cremer
Bernard Klein
Inserm · FRCentre Hospitalier Universitaire de Rennes · FRHeidelberg University · DEUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.

Indexed as

Gene Expression ProfilingOligonucleotide Array Sequence AnalysisB-LymphocytesCell DifferentiationCell Transformation, NeoplasticHumansParaproteinemiasPlasma Cells

Identifiers

PMID16623766
PMCPMC1955683
OpenAlexW2062760281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.