ArticlePLoS biology2006
A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.BMC plant biology · 2025Article
- When should adaptation arise from a polygenic response versus few large effect changes?bioRxiv : the preprint server for biology · 2025Article
- Adaptation of perennial flowering phenology across the European range ofProceedings. Biological sciences · 2023Article
- Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.PLoS biology · 2023Article
- Article
- The use of shared haplotype length information for pedigree reconstruction in asexually propagated outbreeding crops, demonstrated for apple and sweet cherry.Horticulture research · 2021Article
- Diversity and selection of the continuous-flowering gene, RoKSN, in rose.Horticulture research · 2021Article
- Review
- Imputation of 3 million SNPs in the Arabidopsis regional mapping population.The Plant journal : for cell and molecular biology · 2020Article
- Functional variants ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Natural variation in Arabidopsis shoot branching plasticity in response to nitrate supply affects fitness.PLoS genetics · 2019Article
- Linking genes with ecological strategies in Arabidopsis thaliana.Journal of experimental botany · 2019Review
- Assortment of Flowering Time and Immunity Alleles in Natural Arabidopsis thaliana Populations Suggests Immunity and Vegetative Lifespan Strategies Coevolve.Genome biology and evolution · 2018Article
- Natural haplotypes ofeLife · 2017Article
- Article
- Chromosome-level assembly of Arabidopsis thaliana Ler reveals the extent of translocation and inversion polymorphisms.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genome-wide view of genetic diversity reveals paths of selection and cultivar differentiation in peach domestication.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- The Effects of Both Recent and Long-Term Selection and Genetic Drift Are Readily Evident in North American Barley Breeding Populations.G3 (Bethesda, Md.) · 2015Article
- Evolution of CONSTANS Regulation and Function after Gene Duplication Produced a Photoperiodic Flowering Switch in the Brassicaceae.Molecular biology and evolution · 2015Article
12 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
The detection of footprints of natural selection in genetic polymorphism data is fundamental to understanding the genetic basis of adaptation, and has important implications for human health. The standard approach has been to reject neutrality in favor of selection if the pattern of variation at a candidate locus was significantly different from the predictions of the standard neutral model. The problem is that the standard neutral model assumes more than just neutrality, and it is almost always possible to explain the data using an alternative neutral model with more complex demography. Today's wealth of genomic polymorphism data, however, makes it possible to dispense with models altogether by simply comparing the pattern observed at a candidate locus to the genomic pattern, and rejecting neutrality if the pattern is extreme. Here, we utilize this approach on a truly genomic scale, comparing a candidate locus to thousands of alleles throughout the Arabidopsis thaliana genome. We demonstrate that selection has acted to increase the frequency of early-flowering alleles at the vernalization requirement locus FRIGIDA. Selection seems to have occurred during the last several thousand years, possibly in response to the spread of agriculture. We introduce a novel test statistic based on haplotype sharing that embraces the problem of population structure, and so should be widely applicable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.