ArticleMolecular genetics and genomics : MGG2006
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing.
Article in Molecular genetics and genomics : MGG, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Heterochromatin-based silencing of a foreign tandem repeat inbioRxiv : the preprint server for biology · 2025Article
- Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms.Molecular cell · 2024Article
- SetDB1 and Su(var)3-9 are essential for late stages of larval development of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster.Genetics · 2022Article
- Review
- Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.EMBO reports · 2019Article
- Article
- Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 inGenes & development · 2019Article
- Genome-wide analysis of SU(VAR)3-9 distribution in chromosomes of Drosophila melanogaster.Chromosoma · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Drosophila Studies on Autism Spectrum Disorders.Neuroscience bulletin · 2017Review
- Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster.Scientific reports · 2017Article
- Direct interrogation of the role of H3K9 in metazoan heterochromatin function.Genes & development · 2016Article
- Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.PLoS genetics · 2014Article
- Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1.Developmental biology · 2014Article
- SET for life: biochemical activities and biological functions of SET domain-containing proteins.Trends in biochemical sciences · 2013Review
- Transcription-associated histone modifications and cryptic transcription.Biochimica et biophysica acta · 2013Review
- Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation.PLoS genetics · 2011Article
- Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.PLoS biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organization of chromatin structure and regulation of gene transcription are contingent on histone tail modifications. Regions of the genome packaged with nucleosomes that contain methyl histone H3 at lysine 9 (Me K9H3) strongly correlate with regions that are silenced for transcription. To date Su(var)3-9 is the only K9H3 specific enzyme characterized in Drosophila melanogaster. In this study, we describe the identification of three additional Drosophila genes that potentially encode K9H3 specific methyltransferases (HMTase) with homology to known mammalian proteins. By several criteria, including sequence alignments, phylogenic analyses, and enzyme activity of the protein, one of these is a homologue of the human G9a and hence, we name it dG9a. dG9a catalyzes the transfer of methyl groups to full-length histone H3 and to N-terminal H3 peptides that contain lysine 9, suggesting that the major target for dG9a is K9H3. Chromatin extracts prepared from a P-element insert mutation in dG9a display an altered K9H3 methylation profile. In addition, the dG9a mutant is a dominant suppressor of position-effect variegation (PEV), a heterochromatin-associated gene silencing phenomenon. Su(var)3-9 also suppresses PEV. The combined Su(var)3-9 and dG9a mutations have severe developmental defects suggesting an overlapping role for dG9a and Su(var)3-9 in the packaging of heterochromatin and gene silencing via a K9H3 methylation pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.