ArticlePflugers Archiv : European journal of physiology2006
Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Effectiveness of Iso-Inertial Resistance Training on Muscle Power in Middle-Older Adults: Randomized Controlled Trial.JMIR aging · 2025Trial
- Skeletal effects of eccentric strengthening exercise: a scoping review.BMC musculoskeletal disorders · 2023Article
- Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment.European journal of translational myology · 2020Article
- Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice.PloS one · 2018Article
- Improved single muscle fiber quality in the oldest-old.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Therapeutic potential of eccentric exercises for age-related muscle atrophy.Integrative medicine research · 2016Review
- Age-related functional changes and susceptibility to eccentric contraction-induced damage in skeletal muscle cell.Integrative medicine research · 2016Review
- Age-related maintenance of eccentric strength: a study of temperature dependence.Age (Dordrecht, Netherlands) · 2016Article
- Aberrant post-translational modifications compromise human myosin motor function in old age.Aging cell · 2015Article
- Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.Frontiers in physiology · 2014Review
- Human neuromuscular structure and function in old age: A brief review.Journal of sport and health science · 2013Article
- Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Enhanced force production in old age is not a far stretch: an investigation of residual force enhancement and muscle architecture.Physiological reports · 2013Article
- Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults.Age (Dordrecht, Netherlands) · 2012Article
- Increased residual force enhancement in older adults is associated with a maintenance of eccentric strength.PloS one · 2012Article
- Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humans.The Journal of physiology · 2010Article
- Preservation of eccentric strength in older adults: Evidence, mechanisms and implications for training and rehabilitation.Experimental gerontology · 2010Review
- Muscle torque preservation and physical activity in individuals with stroke.Medicine and science in sports and exercise · 2009Article
- Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila.Biophysical journal · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The origins of the smaller age-related decrease in eccentric force compared to isometric and concentric conditions in vivo remain unclear. Could this originate from contractile elements of muscle cells? The main intent of the current investigation was to assess the force behavior of muscle cells with aging, during lengthening. Chemically skinned single muscle fibers (n=235) from m. vastus lateralis of six young (mean age 31.6 years) and six older men (mean age 66.1 years) were maximally activated with pCa 4.5 at 15 degrees C. Maximal isometric force and cross-sectional area were measured allowing the calculation of the tension (T (0)). A quick stretch (2 nm per half-sarcomere length) was applied and caused an immediate increase in tension followed by a decrease and a secondary delayed and transient rise in tension (phase 3); finally, the tension recovered a steady state value (phase 4). The tension enhancements during phase 3 (DeltaT (3)) and phase 4 (DeltaT (4)) were evaluated. The myosin heavy-chain isoform composition of each single fiber was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. DeltaT (3) and DeltaT (4) were preserved in older men for both type I and IIa fibers despite a reduction in T (0). Therefore, the age-related preservation of the tension increments after a quick stretch in single muscle fibers could explain in part the smaller decrease in force during eccentric contractions compared to isometric and concentric conditions in vivo with aging usually observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.