ArticleBritish journal of cancer2006
ATM haplotypes and breast cancer risk in Jewish high-risk women.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals.Journal of clinical laboratory analysis · 2022Article
- Ataxia Telangiectasia-Mutated (Frontiers in public health · 2017Article
- Article
- Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma.The Journal of clinical endocrinology and metabolism · 2012Article
- Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- DNA repair gene polymorphisms and risk of pancreatic cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk.Methods in molecular biology (Clifton, N.J.) · 2009Review
- FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- ATM sequence variants associate with susceptibility to non-small cell lung cancer.International journal of cancer · 2007Article
- Population genomics of human gene expression.Nature genetics · 2007Article
- Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence.Radiation oncology (London, England) · 2007Article
- Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.Breast cancer research : BCR · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While genetic factors clearly play a role in conferring breast cancer risk, the contribution of ATM gene mutations to breast cancer is still unsettled. To shed light on this issue, ATM haplotypes were constructed using eight SNPs spanning the ATM gene region (142 kb) in ethnically diverse non-Ashkenazi Jewish controls (n=118) and high-risk (n=142) women. Of the 28 haplotypes noted, four were encountered in frequencies of 5% or more and accounted for 85% of all haplotypes. Subsequently, ATM haplotyping of high-risk, non-Ashkenazi Jews was performed on 66 women with breast cancer and 76 asymptomatic. One SNP (rs228589) was significantly more prevalent among breast cancer cases compared with controls (P=4 x 10(-9)), and one discriminative ATM haplotype was significantly more prevalent among breast cancer cases (33.3%) compared with controls (3.8%), (P< or =10(-10)). There was no significant difference in the SNP and haplotype distribution between asymptomatic high-risk and symptomatic women as a function of disease status. We conclude that a specific ATM SNP and a specific haplotype are associated with increased breast cancer risk in high-risk non-Ashkenazi Jews.
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