ArticleBritish journal of cancer2006
Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 438 citations in OpenAlex.
- Intraoperative Raman spectroscopy of soft tissue sarcomas.Lasers in surgery and medicine · 2016Trial
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- Deep Learning-Enhanced Raman Microspectroscopy Enables Rapid Microbial Classification and Captures Phylogenetic Relationships.Microorganisms · 2026Article
- Genotypic and Phenotypic Characterisation ofPathogens (Basel, Switzerland) · 2026Article
- Tracking Metabolic Responses to Citalopram in Colon Cells with Raman Spectroscopy.Analytical chemistry · 2026Article
- Visualizing Cytoskeletal Protein Reconstruction of Vulvar Cancer with Surface-Enhanced Raman Spectroscopy and Gold Nanoparticles.ACS omega · 2026Article
- Plasma-based Raman spectroscopy for early detection of acute myocardial infarction in murine models.Scientific reports · 2025Article
- An Interpretable SERS-AI Platform for Rapid and Quantitative Diagnosis of Polymicrobial UTIs: Powered by Positively Charged Plasmonic Nanoparticles and Attention-Based Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging.bioRxiv : the preprint server for biology · 2025Article
- Article
- Machine learning-based SERS serum detection platform for high-sensitive and high-throughput diagnosis of colorectal precancerous lesions.Bioengineering & translational medicine · 2025Article
- Integrating nonlinear optical and Raman spectral imaging for label-free pathological examinations.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Interpretable Multiscale Convolutional Neural Network for Classification and Feature Visualization of Weak Raman Spectra of Biomolecules at Cell Membranes.ACS sensors · 2025Article
- Composite Fish Collagen Peptide-Based Biopolymer Emulsion for Keratin Structure Stabilization and Hair Fiber Repair.Polymers · 2025Article
- Precision Fabrication and Optimization of Nanostructures for Exosome Detection via Surface-Enhanced Raman Spectroscopy.Nanomaterials (Basel, Switzerland) · 2025Article
- Evaluation of Peri-Implantitis through Fourier-Transform Infrared Spectroscopy on Saliva.Journal of proteome research · 2025Article
- SERS profiling of blood serum filtrate components from patients with type II diabetes using 100 kDa filtration devices.RSC advances · 2025Article
- Biochemical components of corneal stroma: a study on myopia classification based on Raman spectroscopy and deep learning methods.Biomedical optics express · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical changes that distinguish between the different stages of disease. Our aim is to understand these changes through Raman mapping studies. Raman spectral mapping was used to analyse 20-microm sections of tissue from 29 snap-frozen oesophageal biopsies. Contiguous haematoxylin and eosin sections were reviewed by a consultant pathologist. Principal component analysis was used to identify the major differences between the spectra across each map. Pseudocolour score maps were generated and the peaks of corresponding loads identified enabling visualisation of the biochemical changes associated with malignancy. Changes were noted in the distribution of DNA, glycogen, lipids and proteins. The mean spectra obtained from selected regions demonstrate increased levels of glycogen in the squamous area compared with increased DNA levels in the abnormal region. Raman spectroscopy is a highly sensitive and specific technique for demonstration of biochemical changes in the carcinogenesis of Barrett's oesophagus. There is potential for in vivo application for real-time endoscopic optical diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.