ArticleBritish journal of cancer2006
A minimally invasive immunocytochemical approach to early detection of oral squamous cell carcinoma and dysplasia.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- CD44-SNA1 integrated cytopathology for delineation of high grade dysplastic and neoplastic oral lesions.PloS one · 2023Pooled it
- Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review.Medicina oral, patologia oral y cirugia bucal · 2015Pooled it
- Thymopoietin-The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Expression of Minichromosome Maintenance Protein 2 (MCM2) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Expression analysis of cyclin D, Ki-67, MCM3 and MCM2 in oral squamous cell carcinoma.Bioinformation · 2023Article
- MCM2 in human cancer: functions, mechanisms, and clinical significance.Molecular medicine (Cambridge, Mass.) · 2022Review
- Article
- Prognostic values and prospective pathway signaling of MicroRNA-182 in ovarian cancer: a study based on gene expression omnibus (GEO) and bioinformatics analysis.Journal of ovarian research · 2019Article
- Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders.Oncology reviews · 2019Article
- Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2017Article
- Early detection and personalized treatment in oral cancer: the impact of omics approaches.Molecular cytogenetics · 2016Review
- Evaluation of Minichromosome Maintenance-3 (MCM3) in Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2015Article
- Replication proteins and human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Can immunohistochemistry serve as an alternative to subjective histopathological diagnosis of oral epithelial dysplasia?Biomarkers in cancer · 2013Review
- A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe.Cell division · 2010Article
- Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas.British journal of cancer · 2009Article
- Article
- MCM immunocytochemistry as a first line cervical screening test in developing countries: a prospective cohort study in a regional cancer centre in India.British journal of cancer · 2007Article
- High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies.Clinical oral investigations · 2007Article
- [Oral cytology: historical development, current status, and perspectives].Mund-, Kiefer- und Gesichtschirurgie : MKG · 2007Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Squamous dysplasia of the oral cavity indicates increased risk of progression to squamous cell carcinoma (SCC). An important advance would be the development of a minimally invasive assay for identification of oral SCC and dysplasia. We have investigated the suitability in this context of immunostaining oral smears for minichromosome maintainance proteins (MCMs), sensitive and specific biomarkers of cell cycle entry. Immunohistochemical examination of 66 oral tissue samples showed a greater frequency of Mcm-2 expression in surface layers of moderate/severe dysplasia and SCC compared to benign keratosis/mild dysplasia. Immunocytochemistry for Mcm-2/Mcm-5 was performed on 101 oral smears. Conventional smears included 23 from normal mucosa, benign proliferative disease and mild dysplasia, all of which were MCM negative. Of 52 conventional smears of SCC tissue samples, 18 were inadequate. However, MCM-positive cells were present in 33/34 adequate samples. Of 26 liquid-based cytology smears, 19 out of 20 smears from SCC were adequate and all were MCM positive. Six smears from benign lesions were adequate and MCM negative. We conclude that MCMs are promising markers for early detection of oral SCC and dysplasia, particularly in a liquid-based cytology platform. Detection of MCMs would be amenable to automation and potentially applicable in the developing world. Further studies are now warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.