ArticleInfection and immunity2006
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 142 citations in OpenAlex.
- Review
- Quantification of Macrophage Cellular Ferrous Iron (FeBio-protocol · 2024Article
- Biology of Anemia: A Public Health Perspective.The Journal of nutrition · 2023Article
- Understanding How Minerals Contribute to Optimal Immune Function.Journal of immunology research · 2023Review
- Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections.Wellcome open research · 2023Review
- Hepcidin regulation in Kenyan children with severe malaria and non-typhoidalHaematologica · 2022Article
- DMT1 Protects Macrophages fromInternational journal of molecular sciences · 2022Article
- Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes.International journal of molecular sciences · 2022Article
- The impact of metal availability on immune function during infection.Trends in endocrinology and metabolism: TEM · 2021Review
- Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice.EBioMedicine · 2021Article
- Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation.JCI insight · 2021Article
- Elemental iron modifies the redox environment of the gastrointestinal tract: A novel therapeutic target and test for metabolic syndrome.Free radical biology & medicine · 2021Article
- "Limiting access to iron decreases infection of Atlantic salmon SHK-1 cells with bacterium Piscirickettsia salmonis".BMC veterinary research · 2021Article
- Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia.Open forum infectious diseases · 2021Article
- Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity.Blood advances · 2021Article
- Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice.Frontiers in cellular and infection microbiology · 2021Article
- Anti-CD206 antibody-conjugated FeOncology letters · 2020Article
- The battle for iron in enteric infections.Immunology · 2020Review
- How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children.International journal of molecular sciences · 2020Review
- The Role of Macrophages inFrontiers in immunology · 2020Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.