ArticleInfection and immunity2006
The Helicobacter pylori cag pathogenicity island protein CagN is a bacterial membrane-associated protein that is processed at its C terminus.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
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- Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.Scientific reports · 2023Article
- Infection withPathogens (Basel, Switzerland) · 2020Article
- Helicobacter pylori Biofilm Formation and Its Potential Role in Pathogenesis.Microbiology and molecular biology reviews : MMBR · 2018Review
- Dynamic Expansion and Contraction ofmBio · 2017Article
- Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.PloS one · 2013Article
- Characterization of CagI in the cag pathogenicity island of Helicobacter pylori.Current microbiology · 2012Article
- A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island.PLoS genetics · 2010Article
- Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex.Journal of bacteriology · 2009Article
- Polymorphism in the CagA EPIYA motif impacts development of gastric cancer.Journal of clinical microbiology · 2009Article
- Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies.Journal of bacteriology · 2008Article
- Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3.Infection and immunity · 2007Article
- Identification of Helicobacter pylori genes that contribute to stomach colonization.Infection and immunity · 2007Article
- The stringent response is required for Helicobacter pylori survival of stationary phase, exposure to acid, and aerobic shock.Journal of bacteriology · 2006Article
- Intestinal vitamin D receptor protects against extraintestinal breast cancer tumorigenesis.Gut microbesArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infects nearly half the world's population and is associated with a spectrum of gastric maladies. Infections with cytotoxin-associated gene pathogenicity island (cag PAI)-containing strains are associated with an increased risk for gastric cancer. The cag PAI contains genes encoding a type IV secretion system (T4SS) and a delivered effector, CagA, that becomes tyrosine phosphorylated upon delivery into host cells and initiates changes in cell signaling. Although some cag PAI genes have been shown to be required for CagA delivery, a subset of which are homologues of T4SS genes from Agrobacterium tumefaciens, the majority have no known function or homologues. We have performed a detailed investigation of one such cag PAI protein, CagN, which is encoded by the gene HP0538. Our results show that CagN is not delivered into host cells and instead is associated with the bacterial membrane. We demonstrate that CagN is cleaved at its C terminus by a mechanism that is independent of other cag PAI proteins. Finally, we show that a delta cagN mutant is not impaired in its ability to deliver CagA to gastric epithelial cells and initiate cell elongation.
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