ArticleJournal of bacteriology2006
LrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Knockout ofJournal of bacteriology · 2026Article
- Aging: a possible road toward gut microbiota pathoadaptation.Gut microbes · 2025Article
- Article
- CRISPR-Cas immunity is repressed by the LysR-type transcriptional regulator PigU.Nucleic acids research · 2024Article
- σeLife · 2023Article
- Spatial regulation of cell motility and its fitness effect in a surface-attached bacterial community.The ISME journal · 2022Article
- Identification of Novel Genes Mediating Survival ofFrontiers in microbiology · 2020Article
- An Osmoregulatory Mechanism Operating through OmpR and LrhA Controls the Motile-Sessile Switch in the Plant Growth-Promoting BacteriumApplied and environmental microbiology · 2019Article
- Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli.Nucleic acids research · 2018Article
- Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli -macrophage interaction.Scientific reports · 2017Article
- Mapping Transposon Insertions in Bacterial Genomes by Arbitrarily Primed PCR.Current protocols in molecular biology · 2017Article
- Article
- HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens.PloS one · 2017Article
- Conditional Proteolysis of the Membrane Protein YfgM by the FtsH Protease Depends on a Novel N-terminal Degron.The Journal of biological chemistry · 2015Article
- RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006.BMC genomics · 2013Article
- Proteomic analysis of the quorum-sensing regulon in Pantoea stewartii and identification of direct targets of EsaR.Applied and environmental microbiology · 2013Article
- A trapping approach reveals novel substrates and physiological functions of the essential protease FtsH in Escherichia coli.The Journal of biological chemistry · 2012Article
- Modelling translation initiation under the influence of sRNA.International journal of molecular sciences · 2012Article
- The RpoS-mediated general stress response in Escherichia coli.Annual review of microbiology · 2011Review
- The LysR-type transcriptional regulator QseD alters type three secretion in enterohemorrhagic Escherichia coli and motility in K-12 Escherichia coli.Journal of bacteriology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Regulation of the Escherichia coli stationary-phase sigma factor RpoS is complex and occurs at multiple levels in response to different environmental stresses. One protein that reduces RpoS levels is the transcription factor LrhA, a global regulator of flagellar synthesis. Here we clarify the mechanism of this repression and provide insight into the signaling pathways that feed into this regulation. We show that LrhA represses RpoS at the level of translation in a manner that is dependent on the small RNA (sRNA) chaperone Hfq. Although LrhA also represses the transcription of the sRNA RprA, its regulation of RpoS mainly occurs independently of RprA. To better understand the physiological signals affecting this pathway, a transposon mutagenesis screen was carried out to find factors affecting LrhA activity levels. The RcsCDB phosphorelay system, a cell envelope stress-sensing pathway, was found to repress lrhA synthesis. In addition, mutations in the gene encoding the DNA motor protein FtsK induce lrhA synthesis, which may explain why such strains fail to accumulate RpoS in stationary phase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.