ReviewJournal of biology2006
Malaria pigment paralyzes dendritic cells.
Review in Journal of biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle.International journal of molecular sciences · 2024Review
- Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression.International journal of molecular sciences · 2023Article
- Article
- Preclinical Study ofCells · 2022Article
- Malaria Pigment Hemozoin Impairs GM-CSF Receptor Expression and Function by 4-Hydroxynonenal.Antioxidants (Basel, Switzerland) · 2021Article
- Expansion of Functional Myeloid-Derived Suppressor Cells in Controlled Human Malaria Infection.Frontiers in immunology · 2021Article
- Hemozoin-induced activation of human monocytes toward M2-like phenotype is partially reversed by antimalarial drugs-chloroquine and artemisinin.MicrobiologyOpen · 2019Article
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Urinalysis and Clinical Correlations in Patients withJournal of tropical medicine · 2017Article
- One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection.Frontiers in microbiology · 2016Article
- Article
- Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda.Tropical medicine & international health : TM & IH · 2015Article
- Article
- Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Observational
- Malarial hemozoin: from target to tool.Biochimica et biophysica acta · 2014Review
- Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.PloS one · 2014Article
- Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.PloS one · 2014Article
- Article
- Effect of malaria components on blood mononuclear cells involved in immune response.Asian Pacific journal of tropical biomedicine · 2013Review
- Immune activation and regulation in simian immunodeficiency virus-Plasmodium fragile-coinfected rhesus macaques.Journal of virology · 2013Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
The capacity of malarial infection to suppress the patient's immune responses both to the parasite and to other antigens has long puzzled researchers. A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.