ArticleThe Journal of infectious diseases2006
Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults.
Article in The Journal of infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial.The Journal of infectious diseases · 2010Trial
- Structural and epitope characterization of anti-DEFA5 monoclonal antibodies clones 1A8 and 4F5 for inflammatory bowel disease subtype diagnostics.International journal of biological macromolecules · 2025Article
- Beyond the Gut: Unveiling Butyrate's Global Health Impact Through Gut Health and Dysbiosis-Related Conditions: A Narrative Review.Nutrients · 2025Review
- Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.Science translational medicine · 2022Article
- Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction.The Journal of infectious diseases · 2021Review
- Induction of Chicken Host Defense Peptides within Disease-Resistant and -Susceptible Lines.Genes · 2020Article
- Homeostasis of the gut barrier and potential biomarkers.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Anti-microbial peptide gene expression during oral vaccination: analysis of a randomized controlled trial.Clinical and experimental immunology · 2016Article
- Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5.Scientific reports · 2016Article
- Safety of live, attenuated oral vaccines in HIV-infected Zambian adults: oral vaccines in HIV.Vaccine · 2012Article
- Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication.The Journal of infectious diseases · 2011Article
- Differential cathelicidin expression in duodenal and gastric biopsies from Tanzanian and German patients.PloS one · 2011Article
- The repertoire of equine intestinal alpha-defensins.BMC genomics · 2009Article
- Susceptibility to infectious diseases based on antimicrobial peptide production.Infection and immunity · 2009Review
- Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins.Clinical and experimental immunology · 2009Article
- Role of the intestinal barrier in inflammatory bowel disease.World journal of gastroenterology · 2008Review
- Alteration in human defensin-5 expression following gastric bypass surgery.Journal of clinical pathology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundHuman defensin (HD) 5 and HD6, both Paneth cell alpha-defensins, contribute to the antimicrobial barrier against intestinal infection. We have previously demonstrated that levels of both HD5 and HD6 mRNA were reduced in adults living in urban Zambia, compared with those in adults living in London. The aim of the present study was to determine, during 2 years of follow-up, whether alpha-defensin expression in Zambian adults is related to susceptibility to diarrhea.
methodsWe analyzed intestinal biopsy samples from a longitudinal cohort study conducted in 83 Zambian adults by quantitative reverse-transcription polymerase chain reaction, Western blotting, immunohistochemistry, and in situ hybridization, and we measured the incidence of diarrhea.
resultsLevels of HD5 and HD6 mRNA in Paneth cells varied between participants, over time, and seasonally and were strongly correlated with mucosal architecture. Gene expression was almost exclusively restricted to Paneth cells. The median (interquartile range) HD5 mRNA level was 6.0 (5.6-6.7) log10 transcripts/microg of total RNA among 18 participants who experienced diarrhea within 2 months after biopsy-sample collection, compared with 6.8 (6.2-7.3) log10 transcripts/microg of total RNA among 94 participants who did not (P=.006). A similar observation was made for HD6.
conclusionsThese data indicate that intestinal alpha-defensin expression is dynamic and seasonal and suggest that susceptibility to intestinal infection is related to alpha-defensin expression.
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Registered trials
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