ArticleMolecular psychiatry2006
Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 115 citations in OpenAlex.
- Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?Translational psychiatry · 2014Trial
- Dopamine modulates reward system activity during subconscious processing of sexual stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- A Hypersexuality Subset Behavior Induced by Aripiprazole Overdose in an Antipsychotic Naïve Patient: A Case Report and Review of the Literature.Clinics and practice · 2026Article
- Exploring the impact of deleterious missense nonsynonymous single nucleotide polymorphisms in the DRD4 gene using computational approaches.Scientific reports · 2025Article
- The Neurometabolic Function of the Dopamine-Aminotransferase System.Metabolites · 2025Review
- Relationship between Serum Neurotransmitters and Cognitive Impairment in Adults with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Review
- Dopamine Increases the Intrinsic Excitability of Parvalbumin-Expressing Fast-Spiking Cells in the Piriform Cortex.Frontiers in cellular neuroscience · 2022Article
- Dopamine: Functions, Signaling, and Association with Neurological Diseases.Cellular and molecular neurobiology · 2019Review
- Evolution of sex-specific pace-of-life syndromes: genetic architecture and physiological mechanisms.Behavioral ecology and sociobiology · 2018Review
- The effect of 8-OH-DPAT and dapoxetine on gene expression in the brain of male rats during ejaculation.Acta pharmaceutica Sinica. B · 2017Article
- Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality.Endocrine connections · 2017Article
- PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.Nature communications · 2015Article
- Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene.Psychiatry research · 2015Article
- Dopamine receptor gene d4 polymorphisms and early sexual onset: gender and environmental moderation in a sample of african-american youth.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Article
- Genetic influences on adolescent sexual behavior: Why genes matter for environmentally oriented researchers.Psychological bulletin · 2014Review
- Factors associated with sexual arousal, sexual sensation seeking and sexual satisfaction among female African American adolescents.Sexual health · 2013Article
- Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.ACS medicinal chemistry letters · 2013Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there is some evidence from twin studies that individual differences in sexual behavior are heritable, little is known about the specific molecular genetic design of human sexuality. Recently, a specific dopamine D4 receptor (DRD4) agonist was shown in rats to induce penile erection through a central mechanism. These findings prompted us to examine possible association between the well-characterized DRD4 gene and core phenotypes of human sexual behavior that included desire, arousal and function in a group of 148 nonclinical university students. We observed association between the exon 3 repeat region, and the C-521T and C-616G promoter region SNPs, with scores on scales that measure human sexual behavior. The single most common DRD4 5-locus haplotype (19%) was significantly associated with Desire, Function and Arousal scores. The current results are consistent with animal studies that show a role for dopamine and specifically the DRD4 receptor in sexual behavior and suggest that one pathway by which individual variation in human desire, arousal and function are mediated is based on allelic variants coding for differences in DRD4 receptor gene expression and protein concentrations in key brain areas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.