ArticleProceedings of the National Academy of Sciences of the United States of America2006
Domain architecture and structure of the bacterial cell division protein DivIB.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Structural basis for the coordination of cell division with the synthesis of the bacterial cell envelope.Protein science : a publication of the Protein Society · 2019Review
- PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.Cellular and molecular life sciences : CMLS · 2018Article
- Delineating FtsQ-mediated regulation of cell division inThe Journal of biological chemistry · 2018Article
- Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis.Journal of bacteriology · 2018Article
- The polypeptide transport-associated (POTRA) domains of TpsB transporters determine the system specificity of two-partner secretion systems.The Journal of biological chemistry · 2014Article
- Article
- Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.BMC structural biology · 2011Article
- Evidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic β domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2B.Journal of bacteriology · 2010Article
- Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp.Microbiology and molecular biology reviews : MMBR · 2010Review
- Central domain of DivIB caps the C-terminal regions of the FtsL/DivIC coiled-coil rod.The Journal of biological chemistry · 2009Article
- Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: an interspecies approach to the study of protein-protein interactions in multiprotein complexes.Journal of bacteriology · 2008Article
- Roles of pneumococcal DivIB in cell division.Journal of bacteriology · 2008Article
- Contribution of the FtsQ transmembrane segment to localization to the cell division site.Journal of bacteriology · 2007Article
- Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly.Journal of bacteriology · 2007Article
- Requirement for the cell division protein DivIB in polar cell division and engulfment during sporulation in Bacillus subtilis.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial cytokinesis requires the coordinated assembly of a complex of proteins, collectively known as the divisome, at the incipient division site. DivIB/FtsQ is a conserved component of the divisome in bacteria with cell walls, suggesting that it plays a role in synthesis and/or remodeling of septal peptidoglycan. We demonstrate that the extracytoplasmic region of DivIB comprises three discrete domains that we designate alpha, beta, and gamma from the N to C terminus. The alpha-domain is proximal to the cytoplasmic membrane and coincident with the polypeptide transport-associated domain that was proposed previously to function as a molecular chaperone. The beta-domain has a unique 3D fold, with no eukaryotic counterpart, and we show that it interconverts between two discrete conformations via cis-trans isomerization of a Tyr-Pro peptide bond. We propose that this isomerization might modulate protein-protein interactions of the flanking alpha- and gamma-domains. The C-terminal gamma-domain is unstructured in the absence of other divisomal proteins, but we show that it is critical for DivIB function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.