ArticleGenetics in medicine : official journal of the American College of Medical Genetics2006
Evaluation of a decision aid for families considering p53 genetic counseling and testing.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- The Influence of Adolescence on Parents' Perspectives of Testing and Discussing Inherited Cancer Predisposition.Journal of genetic counseling · 2018Article
- Development and Initial Assessment of a Patient Education Video about Pharmacogenetics.Journal of personalized medicine · 2017Article
- Development and preliminary evaluation of an online educational video about whole-genome sequencing for research participants, patients, and the general public.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Defining Our Clinical Practice: The Identification of Genetic Counseling Outcomes Utilizing the Reciprocal Engagement Model.Journal of genetic counseling · 2016Article
- Childhood predictive genetic testing for Li-Fraumeni syndrome.Familial cancer · 2010Article
- Psychological functioning in persons considering genetic counseling and testing for Li-Fraumeni syndrome.Psycho-oncology · 2008Article
- Assessment of psychosocial outcomes in genetic counseling research: an overview of available measurement scales.Journal of genetic counseling · 2007Article
- Psychometric testing of the decisional conflict scale: genetic testing hereditary breast and ovarian cancer.Nursing researchArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
purposeLi-Fraumeni syndrome (LFS) is associated with p53 germline mutations, and carriers are at increased risk for multiple primary cancers. We evaluated outcomes following the administration of a video-based decision aid (DA) prior to clinical p53 genetic counseling and testing among persons who had previously participated in cancer genetics research.
methodsFifty-seven individuals at risk for a known p53 mutation completed baseline and post-DA measures of psychological outcomes, plus knowledge and attitudes regarding p53 genetic testing. Counseling and testing uptake also was recorded.
resultsAt baseline, multivariate analysis showed that greater testing intention was associated with lower decisional conflict (P < 0.01). Compared with baseline data, multivariate analyses of post-DA outcomes showed that knowledge about LFS and genetic testing increased and decisional conflict related to testing decreased (P < 0.001). Mean cancer worries scores decreased among all participants (P < 0.001), and mean depression scores decreased for males (P < 0.05). Thirty-nine (68%) completed pre-test genetic counseling and 23 (40%) subsequently gave a blood sample for clinical genetic testing.
conclusionThis intervention was useful as an initial outreach and educational method for families considering p53 genetic testing, and may improve knowledge about LFS as well as psychological outcomes.
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Registered trials
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