ArticleProceedings of the National Academy of Sciences of the United States of America2006
Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Humanization for neurological disease modeling: A roadmap to increase the potential of Drosophila model systems.Animal models and experimental medicine · 2023Article
- Gαi protein subunit: A step toward understanding its non-canonical mechanisms.Frontiers in cell and developmental biology · 2022Review
- Diversity of activator of G-protein signaling (AGS)-family proteins and their impact on asymmetric cell division across taxa.Developmental biology · 2020Review
- Antagonistic PCP Signaling Pathways in the developing Drosophila eye.Scientific reports · 2018Article
- Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia inBiology open · 2017Article
- Mode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides.Bioscience reports · 2015Article
- Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.Development (Cambridge, England) · 2014Article
- Frizzled receptors signal through G proteins.Cellular signalling · 2013Article
- Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.PloS one · 2013Article
- Wnt/beta-catenin signaling and small molecule inhibitors.Current pharmaceutical design · 2013Review
- Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Gαo-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Review
- Article
- Differentiation of human T cells alters their repertoire of G protein alpha-subunits.The Journal of biological chemistry · 2010Article
- Article
- Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling.Molecular biology of the cell · 2009Article
- Molecular mechanisms of go signaling.Neuro-Signals · 2009Review
- Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.Developmental cell · 2008Article
- The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster.BMC developmental biology · 2008Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
During asymmetric division, a cell polarizes and differentially distributes components to its opposite ends. The subsequent division differentially segregates the two component pools to the daughters, which thereby inherit different developmental directives. In Drosophila sensory organ precursor cells, the localization of Numb protein to the cell's anterior cortex is a key patterning event and is achieved by the combined action of many proteins, including Pins, which itself is localized anteriorly. Here, a role is described for the trimeric G protein Go in the anterior localization of Numb and daughter cell fate specification. Go is shown to interact with Pins. In addition to a role in recruiting Numb to an asymmetric location in the cell's cortex, Go transduces a signal from the Frizzled receptor that directs the position in which the complex forms. Thus, Go likely integrates the signaling that directs the formation of the complex with the signaling that directs where the complex forms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.