ArticlePlant physiology2006
Subcellular localization and membrane topology of the melon ethylene receptor CmERS1.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- Spatiotemporal dynamics of ethylene biosynthesis shape infection and nodule initiation in Medicago truncatula.The Plant cell · 2026Article
- A cargo sorting receptor mediates chloroplast protein trafficking through the secretory pathway.The Plant cell · 2024Article
- Ethylene Signaling under Stressful Environments: Analyzing Collaborative Knowledge.Plants (Basel, Switzerland) · 2022Review
- Isolation of theFrontiers in microbiology · 2021Article
- Comparative genomics of muskmelon reveals a potential role for retrotransposons in the modification of gene expression.Communications biology · 2020Article
- Ethylene signaling in plants.The Journal of biological chemistry · 2020Review
- Structural Model of the ETR1 Ethylene Receptor Transmembrane Sensor Domain.Scientific reports · 2019Article
- Membrane protein MHZ3 stabilizes OsEIN2 in rice by interacting with its Nramp-like domain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses.Plant physiology · 2018Article
- Differentially localized rice ethylene receptors OsERS1 and OsETR2 and their potential role during submergence.Plant signaling & behavior · 2017Article
- Mechanistic Insights in Ethylene Perception and Signal Transduction.Plant physiology · 2015Review
- Identification of Regions in the Receiver Domain of the ETHYLENE RESPONSE1 Ethylene Receptor of Arabidopsis Important for Functional Divergence.Plant physiology · 2015Article
- Ethylene-induced inhibition of root growth requires abscisic acid function in rice (Oryza sativa L.) seedlings.PLoS genetics · 2014Article
- Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis.The Plant journal : for cell and molecular biology · 2014Article
- Ethylene signaling and regulation in plant growth and stress responses.Plant cell reports · 2013Review
- Mechanisms of signal transduction by ethylene: overlapping and non-overlapping signalling roles in a receptor family.AoB PLANTS · 2013Article
- Ligand-induced alterations in the phosphorylation state of ethylene receptors in tomato fruit.Plant physiology · 2012Article
- Advances in ethylene signalling: protein complexes at the endoplasmic reticulum membrane.AoB PLANTS · 2012Article
- Tomato TILLING technology: development of a reverse genetics tool for the efficient isolation of mutants from Micro-Tom mutant libraries.Plant & cell physiology · 2011Article
- Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings.Plant physiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethylene receptors are multispanning membrane proteins that negatively regulate ethylene responses via the formation of a signaling complex with downstream elements. To better understand their biochemical functions, we investigated the membrane topology and subcellular localization of CmERS1, a melon (Cucumis melo) ethylene receptor that has three putative transmembrane domains at the N terminus. Analyses using membrane fractionation and green fluorescent protein imaging approaches indicate that CmERS1 is predominantly associated with the endoplasmic reticulum (ER) membrane. Detergent treatments of melon microsomes showed that the receptor protein is integrally bound to the ER membrane. A protease protection assay and N-glycosylation analysis were used to determine membrane topology. The results indicate that CmERS1 spans the membrane three times, with its N terminus facing the luminal space and the large C-terminal portion lying on the cytosolic side of the ER membrane. This orientation provides a platform for interaction with the cytosolic signaling elements. The three N-terminal transmembrane segments were found to function as topogenic sequences to determine the final topology. High conservation of these topogenic sequences in all ethylene receptor homologs identified thus far suggests that these proteins may share the same membrane topology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.