ArticleBiophysical journal2006
Controlling the protein dynamical transition with sugar-based bioprotectant matrices: a neutron scattering study.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effect of water activity on the mechanical glass transition and dynamical transition of bacteria.Biophysical journal · 2022Article
- The Dynamics of Hydrated Proteins Are the Same as Those of Highly Asymmetric Mixtures of Two Glass-Formers.ACS omega · 2021Article
- Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase.Biomolecules · 2020Article
- Evaluation of Predictors of Protein Relative Stability Obtained by Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR.Pharmaceutical research · 2020Article
- Investigating Structure and Dynamics of Proteins in Amorphous Phases Using Neutron Scattering.Computational and structural biotechnology journal · 2017Review
- Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids.Current pharmaceutical design · 2015Review
- Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry. 1. Exchange mapping.Molecular pharmaceutics · 2012Article
- Softness of atherogenic lipoproteins: a comparison of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) using elastic incoherent neutron scattering (EINS).Journal of the American Chemical Society · 2011Article
- Mean-squared atomic displacements in hydrated lysozyme, native and denatured.Journal of biological physics · 2010Article
- From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature.Biophysical journal · 2009Article
- Observation of a low-temperature, dynamically driven structural transition in a polypeptide by solid-state NMR spectroscopy.Journal of the American Chemical Society · 2009Article
- Dynamics of C-phycocyanin in various deuterated trehalose/water environments measured by quasielastic and elastic neutron scattering.European biophysics journal : EBJ · 2008Article
- Thermal fluctuations of DNA enclosed by glycerol-water glassy matrices: an elastic neutron scattering investigation.European biophysics journal : EBJ · 2008Article
- Dynamics of hydration water in deuterated purple membranes explored by neutron scattering.European biophysics journal : EBJ · 2008Article
- Hydration dependent dynamics in sol-gel encapsulated myoglobin.European biophysics journal : EBJ · 2008Article
- Differences in internal dynamics of actin under different structural states detected by neutron scattering.Biophysical journal · 2008Article
- The role of protein-solvent hydrogen bond dynamics in the structural relaxation of a protein in glycerol versus water.European biophysics journal : EBJ · 2008Article
- How a vicinal layer of solvent modulates the dynamics of proteins.Biophysical journal · 2008Article
- Coupling of protein and hydration-water dynamics in biological membranes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Temperature dependence of protein dynamics as affected by sugars: a neutron scattering study.European biophysics journal : EBJ · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Through elastic neutron scattering we measured the mean-square displacements of the hydrogen atoms of lysozyme embedded in a glucose-water glassy matrix as a function of the temperature and at various water contents. The elastic intensity of all the samples has been interpreted in terms of the double-well model in the whole temperature range. The dry sample shows an onset of anharmonicity at approximately 100 K, which can be attributed to the activation of methyl group reorientations. Such a protein intrinsic dynamics is decoupled from the external environment on the whole investigated temperature range. In the hydrated samples an additional and larger anharmonic contribution is provided by the protein dynamical transition, which appears at a higher temperature Td. As hydration increases the coupling between the protein internal dynamics and the surrounding matrix relaxations becomes more effective. The behavior of Td that, as a function of the water content, diminishes by approximately 60 K, supports the picture of the protein dynamics as driven by solvent relaxations. A possible connection between the protein dynamical response versus T and the thermal stability in glucose-water bioprotectant matrices is proposed.
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