ArticleDigestive diseases and sciences2006
Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasia.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Intestinal stem cells promote crypt fission during postnatal growth of the small intestine.BMJ open gastroenterology · 2020Article
- Active β-Catenin Signaling in the Small Intestine of Humans During Infancy.Digestive diseases and sciences · 2019Article
- Adaptive Physiological and Morphological Adjustments Mediated by Intestinal Stem Cells in Response to Food Availability in Mice.Frontiers in physiology · 2018Article
- Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.PLoS biology · 2016Article
- Organ-Size Regulation in Mammals.Cold Spring Harbor perspectives in biology · 2015Review
- Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.Infection and immunity · 2013Article
- Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies.Tissue barriers · 2013Review
- Notch signaling promotes intestinal crypt fission in the infant rat.Digestive diseases and sciences · 2013Article
- Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestine.American journal of physiology. Cell physiology · 2012Article
- Time-resolved quantitative proteome analysis of in vivo intestinal development.Molecular & cellular proteomics : MCP · 2011Article
- Article
- The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.Cell death and differentiation · 2008Article
- Impaired growth of small intestinal epithelium by adrenalectomy in weaning rats.Acta histochemica et cytochemica · 2008Article
- Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.Digestive diseases and sciences · 2007Article
- Age-related histomorphologic changes in the canine gastrointestinal tract: a histologic and immunohistologic study.World journal of gastroenterology · 2007Article
- Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.Gut microbesArticle
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Authors and funding
3 authors.
Funding
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Abstract
Studies of growth of the small intestine have largely concentrated on crypt hyperplasia rather than crypt fission. The aim of this study was to investigate quantitatively both crypt fission and crypt hyperplasia. DAxPVG/c rats were killed at 7, 11, 14, 17, 19, 21, 25, 55, and 72-73 days of life. Samples of jejunum at one third of the intestinal length were taken for morphometry (villous area, crypt area, percentage of bifid crypts, and crypt mitotic count) by microdissection. Growth factors and their receptors were assessed by oligonucleotide microarray. Crypt fission was 10.5%, 5.2%, and 1.5% at days 11, 25, and 72-73 of life, respectively. Crypt hyperplasia increased from day 21. No conventional growth factor was identified during crypt fission. We conclude that crypt fission contributes to growth of the small intestine prior to weaning and crypt hyperplasia to growth after weaning.
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