ArticleDigestive diseases and sciences2006
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 104 citations in OpenAlex.
- Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.Journal of immunology (Baltimore, Md. : 1950) · 2012Trial
- Characteristics of T-Cells Expressing IL-37 and Its Receptors in Inflammatory Bowel Disease.International journal of molecular sciences · 2026Article
- T Regulatory Cells in Inflammatory Bowel Disease-Are They Major Players?International journal of molecular sciences · 2025Review
- Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells.Frontiers in immunology · 2025Review
- Helicobacter Pylori infection in children with inflammatory bowel disease: a prospective multicenter study.BMC pediatrics · 2024Article
- Exploring Colitis through Dynamic T Cell Adoptive Transfer Models.Inflammatory bowel diseases · 2023Article
- Anti-inflammatory cytokines in sickle cell disease.Molecular biology reports · 2022Review
- Evaluation of the relationship between the spleen volume and the disease activity in ulcerative colitis and Crohn disease.Medicine · 2022Article
- Article
- Prevalence of Autoimmune Disease in Patients with Eosinophilic Esophagitis: A Cross-sectional Study of Three Hospitals in Japan.Internal medicine (Tokyo, Japan) · 2021Article
- Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.Molecular systems biology · 2021Article
- Increased frequency of regulatory T cells in pediatric inflammatory bowel disease at diagnosis: a compensative role?Pediatric research · 2020Article
- Development of Quantitative Methylation-Specific Droplet Digital PCR (ddMSP) for Assessment of Natural Tregs.Frontiers in genetics · 2020Article
- Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review.Mediators of inflammation · 2020Review
- Review
- Kuijieling-Containing Serum Regulates Th17 and Treg Cell Differentiation by Inhibiting STAT3 SignalingEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses.Mucosal immunology · 2018Article
- Immunotherapy in inflammatory bowel disease: Novel and emerging treatments.Human vaccines & immunotherapeutics · 2018Article
- Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3Frontiers in immunology · 2017Article
- Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches.World journal of gastroenterology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that CD4+CD25+ regulatory T cells play a crucial role in the suppression of intestinal inflammation. However, their role in the suppression of inflammatory bowel disease has not yet been addressed. We examined the proportion of regulatory T cells in inflammatory bowel disease. First, we isolated CD4+CD45RO+CD25+ T cells from the peripheral blood of healthy persons and showed that these cells suppressed T cell proliferation profoundly and expressed FoxP3 abundantly, revealing that they are regulatory cells. Then the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry. CD4+CD45RO+CD25+ T cell frequency was significantly lower in active ulcerative colitis than in the control and inactive ulcerative colitis. CD4+CD45RO+CD25+ T cell frequency was inversely correlated with the clinical and endoscopic severity of ulcerative colitis. These results suggest that a deficiency of regulatory T cells is associated with the progression of ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.