ArticleDigestive diseases and sciences2006
A novel external esophageal perfusion model for reflux esophageal injury.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of phenytoin on ethanol-induced gastric ulceration in rats: involvement of oxidative stress, inflammation, and apoptosis.Journal of pharmaceutical health care and sciences · 2026Article
- Atractylenolide III ameliorated reflux esophagitis via PI3K/AKT/NF-κB/iNOS pathway in rats.Heliyon · 2023Article
- A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans.Frontiers in veterinary science · 2022Review
- Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma-Past, Present, and Future.Clinical and translational science · 2015Review
- From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma.World journal of gastroenterology · 2015Review
- Acetaldehyde is an oxidative stressor for gastric epithelial cells.Journal of clinical biochemistry and nutrition · 2014Article
- Alcohol is an oxidative stressor for gastric epithelial cells: detection of superoxide in living cells.Journal of clinical biochemistry and nutrition · 2013Article
- Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma.International journal of nanomedicine · 2013Article
- The resistance of esophageal adenocarcinoma to bile salt insult is associated with manganese superoxide dismutase expression.The Journal of surgical research · 2011Article
- Positive correlation of image analysis by mini-endoscopy with micro-PET scan and histology in rats after esophagoduodenal anastomosis.Surgical endoscopy · 2010Article
- Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity.World journal of gastroenterology · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current animal models of esophagitis and Barrett's esophagus consist of surgeries that divert the gastroduodenal contents to the esophagus. The limitations of these models are the inability to control the amount and concentration of the refluxate and the causing of significant postoperative stress and morbidity. Eighteen adult rats were cannulated at the upper esophagus and connected to a subcutaneous osmotic micropump to perfuse the esophageal lumen with bile and acid. Animals were sacrificed after 7 days of perfusion. Histological changes were determined. Cell proliferation, apoptosis, lipid peroxidation, and glutathione were measured. Histopathological changes in the bile- or acid-perfused esophagus were consistent with the findings associated with reflux esophagitis. Enhanced proliferation and apoptosis were seen, along with increased oxidative stress. The external esophageal perfusion model enabled precise control of the injurious agent. It induced the histologic and cellular injury of reflux esophagitis after 7 days.
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