ArticleProceedings of the National Academy of Sciences of the United States of America2006
Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Advances towards the completeFaculty reviews · 2023Review
- Functional roles of cytokines in infectious disease associated colorectal carcinogenesis.Molecular biology reports · 2022Review
- Influence of the Host and Parasite Strain on the Immune Response DuringFrontiers in cellular and infection microbiology · 2020Review
- Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak.BMC infectious diseases · 2019Article
- Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity.Human vaccines & immunotherapeutics · 2017Review
- Attenuated Toxoplasma gondii Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations.Cancer immunology research · 2015Article
- CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection.Seminars in immunopathology · 2015Review
- Article
- Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis.PloS one · 2015Article
- Modulation of the host Th1 immune response in pigeon protozoal encephalitis caused by Sarcocystis calchasi.Veterinary research · 2013Article
- IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite.Microbes and infection · 2012Article
- Epidemiology of and diagnostic strategies for toxoplasmosis.Clinical microbiology reviews · 2012Review
- The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.Microbes and infection · 2012Review
- The CD8 T-cell road to immunotherapy of toxoplasmosis.Immunotherapy · 2011Review
- CD8 T Cells and Toxoplasma gondii: A New Paradigm.Journal of parasitology research · 2011Article
- Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii.PloS one · 2010Article
- Effect of interleukin-15 on the course of myocarditis in Coxsackievirus B3-infected BALB/c mice.The Canadian journal of cardiology · 2009Article
- New insights into the regulation of T cells by gamma(c) family cytokines.Nature reviews. Immunology · 2009Review
- Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Coinfection with Heligmosomoides polygyrus fails to establish CD8+ T-cell immunity against Toxoplasma gondii.Infection and immunity · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
IFN-gamma-producing CD4+ T cells, although important for protection against acute Toxoplasma gondii infection, can cause gut pathology, which may prove to be detrimental for host survival. Here we show that mice lacking IL-15 gene develop a down-regulated IFN-gamma-producing CD4+ T cell response against the parasite, which leads to a reduction in gut necrosis and increased level of survival against infection. Moreover, transfer of immune CD4+ T cells from WT to IL-15-/- mice reversed inhibition of gut pathology and caused mortality equivalent to levels of parental WT mice. Down-regulated CD4+ T cell response in the absence of IL-15, manifested as reduced antigen-specific proliferation, was due to defective priming of the T cell subset by dendritic cells (DCs) of these animals. When stimulated with antigen-pulsed DCs from WT mice, CD4+ T cells from IL-15-/- mice were primed optimally, and robust proliferation of these cells was observed. A defect in the DCs of knockout mice was further confirmed by their reduced ability to produce IL-12 upon stimulation with Toxoplasma lysate antigen. Addition of exogenous IL-15 to DC cultures from knockout mice led to increased IL-12 production by these cells and restored their ability to prime an optimal parasite-specific CD4+ T cell response. To our knowledge, this is the first demonstration of the role of IL-15 in the development of CD4+ T cell immunity against an intracellular pathogen. Furthermore, based on these observations, targeting of IL-15 should have a beneficial effect on individuals suffering from CD4+ T cell-mediated autoimmune diseases.
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