ArticleThe British journal of ophthalmology2006
Stage of presentation and visual outcome of patients screened for familial retinoblastoma: nationwide registration in the Netherlands.
Article in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating whole genome sequencing for rare diseases in newborn screening: evidence synthesis from a series of systematic reviews.Health technology assessment (Winchester, England) · 2025Pooled it
- Population-based genomic detection of childhood cancer predisposition using newborn dried blood spots.Nature communications · 2026Article
- Retinoblastoma and vision.Eye (London, England) · 2023Review
- At What Age Could Screening for Familial Retinoblastoma Be Discontinued? A Systematic Review.Cancers · 2021Article
- An Online Application for Retinoblastoma Surveillance.Ocular oncology and pathology · 2020Article
- Outcomes of neonatal retinoblastoma in pre-chemotherapy and chemotherapy eras.Indian journal of ophthalmology · 2019Article
- Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign.Translational vision science & technology · 2018Article
- Retinoblastoma and Neuroblastoma Predisposition and Surveillance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Review
- Recent advances and challenges in the management of retinoblastoma.Indian journal of ophthalmology · 2017Review
- Genetic causes of cancer predisposition in children and adolescents.Translational pediatrics · 2015Review
- Management of familial cancer: sequencing, surveillance and society.Nature reviews. Clinical oncology · 2014Review
- Detection of leukocoria using a soft fusion of expert classifiers under non-clinical settings.BMC ophthalmology · 2014Article
- Familial retinoblastoma: fundus screening schedule impact and guideline proposal. A retrospective study.Eye (London, England) · 2011Article
- Health-related quality of life of child and adolescent retinoblastoma survivors in the Netherlands.Health and quality of life outcomes · 2007Article
- Quality of life of adult retinoblastoma survivors in the Netherlands.Health and quality of life outcomes · 2007Article
- Neonatal retinoblastoma: A study of five cases.Oman journal of ophthalmologyArticle
- Neonatal Retinoblastoma.Asia-Pacific journal of oncology nursingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the Netherlands a comprehensive programme for screening just after birth for familial retinoblastoma is taking place. In this report the stage of the disease at the time of detection, by way of screening, and the long term visual outcome in these patients was evaluated.
methodsA nationwide, retrospective study. From January 1992-July 2004, patients at risk for familial retinoblastoma were screened 1-2 weeks after birth, and investigated for laterality, Reese-Ellsworth classification/International Classification of Retinoblastoma, macular involvement, age of primary retinoblastoma, initial therapy, and visual outcome.
results17 patients were diagnosed with familial retinoblastoma. 88.3% developed bilateral, 11.7% unilateral retinoblastoma. Of the 34 eyes, 56% were R-E group I, 16% were group II A-B, 16% were group III A-B, 9% were group IV, 3% were group V. Using the International Classification of Retinoblastoma, 72% were group A, 19% were group B, 6% were group C, 3% were group E. The visual outcome revealed 73.5% of eyes with 20/20-20/40, 26.5% eyes with < or = 20/100-no light perception; 5.9% of eyes were enucleated, all other eyes were treated with local or conservative treatment methods. Of all eyes, 59% had extramacular retinoblastoma, 98% of patients had at least one eye with extramacular retinoblastoma.
conclusionMost familial retinoblastoma patients present as a R-E group I or group A when screened within 2 weeks after birth. Nearly 90% of patients had a long term visual acuity of 20/20-20/40. Despite the common occurrence of macula involvement, bilateral macula involvement was infrequent, and since most eyes were salvaged, good vision was obtained in the majority of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.