ArticleThe Journal of physiology2006
Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 107 citations in OpenAlex.
- Psychosomatics at the threshold: cancer, mood disorders, and the mental pain of death - where precision medicine meets spirituality.Frontiers in psychiatry · 2026Article
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- Dorsal and median raphe neuronal firing dynamics characterized by nonlinear measures.PLoS computational biology · 2024Article
- Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons.bioRxiv : the preprint server for biology · 2023Article
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
- Calcium, Bioenergetics, and Parkinson's Disease.Cells · 2020Review
- Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.Nature communications · 2020Article
- Selective activation of serotoninergic dorsal raphe neurons facilitates sleep through anxiolysis.Sleep · 2020Article
- Circuit mechanisms and computational models of REM sleep.Neuroscience research · 2019Review
- Identified Serotonergic Modulatory Neurons Have Heterogeneous Synaptic Connectivity within the Olfactory System ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Divergent in vivo activity of non-serotonergic and serotonergic VGluT3-neurones in the median raphe region.The Journal of physiology · 2016Article
- Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- Serotonin increases synaptic activity in olfactory bulb glomeruli.Journal of neurophysiology · 2016Article
- Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices.Frontiers in cellular neuroscience · 2016Article
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- Article
- Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus.Journal of chemical neuroanatomy · 2014Article
- Potential effects of cannabidiol as a wake-promoting agent.Current neuropharmacology · 2014Article
- Chronic escitalopram treatment caused dissociative adaptation in serotonin (5-HT) 2C receptor antagonist-induced effects in REM sleep, wake and theta wave activity.Experimental brain research · 2014Article
- Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation.ACS chemical neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Through their widespread projections to the entire brain, dorsal raphe cells participate in many physiological functions and are associated with neuropsychiatric disorders. In previous studies, the width of action potentials was used as a criterion to identify putative serotonergic neurons, and to demonstrate that cells with broad spikes were more active in wakefulness, slowed down their activity in slow wave sleep and became virtually silent during paradoxical sleep. However, recent studies reported that about half of these presumed serotonergic cells were not immunoreactive for tyrosine hydroxylase. Here, we re-examine the electrophysiological properties of dorsal raphe cells across the sleep-wake cycle in rats by the extracellular recording of a large sample of single units (n = 770). We identified two major types of cells, which differ in spike waveform: a first population characterized by broad, mostly positive spikes, and a second one displaying symmetrical positive-negative spikes with a large distribution of spike durations (0.6-3.2 ms). Although we found classical broad-spike cells that were more active in wakefulness, we also found that about one-third of these cells increased or did not change their firing rate during sleep compared with wakefulness. Moreover, 62% of the latter cells were active in paradoxical sleep when most of raphe cells were silent. Such a diversity in the neuronal firing behaviour is important in the light of the recent controversy regarding the neurochemical identity of dorsal raphe cells exhibiting broad spikes. Our results also suggest that the dorsal raphe contains subpopulations of neurons with reciprocal activity across the sleep-wake cycle.
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